JAHA: Association between autoimmune vasculitis and atrial fibrillation.

Recent studies have shown that inflammation and autoimmunity may be associated with the pathophysiological mechanisms of atrial fibrillation.
recently, a study published in JAHA, an authoritative journal in the field of cardiovascular disease, suggests that autoimmune vasculitis plays an important role in the pathogenesis of atrial fibrillation, given that abnormal atrial vascular coupling often coexists with atrial fibrillation.
conducted a population-based, standardized retrospective case-control study to assess the association between autoimmune vasculitis and atrial fibrillation and all-cause mortality.
the study included 8,459 newly diagnosed patients with atrial fibrillation and 8,459 controls matching age, sex and year of registration in Olmsted County, Minnesota, between January 1, 1980 and December 31, 2010.
researchers used conditional Logistic regression to assess the correlation between clinical characteristics, diagnosis and treatment.
Cox proportional risk regression model and Kaplan-Meier curve were used to detect independent predictors of death and assess cumulative survival rates.
over a 30-year period, the study included a total of 16,918 patients with atrial fibrillation (average age 72.3 plus 14.4 years; 48.7 percent of women) and 320 (1.9 percent) of subjects diagnosed with autoimmune vasculitis.
in these cases, the prevalence of any autoimmune vasculitis was 2.3%, while the prevalence of autoimmune vasculitis in the control group was 1.5%.
the potential mixing factors, patients with atrial fibrillation were 1.5 times more likely to have autoimmune vasculitis (ratio of 1.47; 95% CI was 1.04-2.01; P=0.03).
compared to patients without autoimmune vasculitis or atrial fibrillation, atrial fibrillation patients with autoimmune vasculitis had a poor five-year survival rate (44.7% vs. 77.2%;
, autoimmune vasculitis is significantly associated with atrial fibrillation and can independently lead to poor survival outcomes.
these observations may indicate a mechanism that can link autoimmune and inflammation to the pathogenesis and prognostois of atrial fibrillation.
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