JACS: Developing simple molecular preparations for Alzheimer's disease

2020610/
BIOON/ --,,
Journal of the American Chemical Society
,,。Photo Source: The Korea Advanced Institute of Science and Technology (KAIST)In the article, researchers have developed a simple structure, oxidizing aromatic molecular formulation that simultaneously targets and regulates multiple pathological factors in complex neurodegenerative diseases such as Alzheimer's disease, one of the most popular neurodegenerative diseases that affects the health of one in ten individuals over the age of 65, and early-onset dementia is increasingly affecting the health of young peoplea variety of pathogenic components such as reactive oxygen, beta amyloid, and metal ions are considered potential causes of Alzheimer's disease, each of which can lead to the development of Alzheimer's disease, but their interactions may exacerbate the patient's condition and interfere with appropriate clinical careFor example, when interacting with beta amyloid, metal ions promote the aggregation of beta amyloid peptides, which induces oxidative stress and toxic reactions in the brain and leads to neurodegenerative diseasebecause of the interwoven nature of the various pathogenic factors that induce Alzheimer's disease, the development of therapeutic agents that simultaneously regulate the dynamic balance of metal ions, beta amyloid coagulation and oxidative stress reactions may be the key to blocking disease progressionIn this study, the researchers demonstrated the feasibility of molecular design based on structural mechanisms that can control the chemical reaction of molecules to a variety of pathological factors in Alzheimer's disease by regulating the redox properties of moleculesResearcher Lim said that by adjusting the electron distribution of benzene, styrene and argon, we reasonably designed and produced 10 close aromatic molecules that showed a series of redox potentials, resulting in a redox-dependent reaction to a variety of pathogenic factors in Alzheimer's diseaseduring biochemical and biophysical studies, these designed molecular agents were able to exhibit redox-dependent reactions at a variety of ideal targets associated with Alzheimer's disease, such as free radicals, metal-free beta amyloid proteins, and metal-bound amyloid proteinsFurther mechanical studies show that the redox properties of these designed molecular formulations are very important to their function, and these preparations participate in the oxidation of metal- and metal-bound beta amyloid proteins and produce certain chemical modificationsIn addition, the most promising candidate molecules can significantly reduce the pathological performance of amyloid in the brains of genetically modified mice with Alzheimer's disease, and can improve cognitive impairment in mice'This new strategy is simple, time-saving, cost-effective and effective, and we're excited to advance the development of new neurodegenerative disease drugs to improve the quality of life for patients,' said Lim, aresearcher (BioValleyBioon.com) original origins: Mingeun Kim, Juhye Kang, Misun Lee, et al.
The Ethereing Principles for Designing Small Molecules with Multiple Reactiveies Against S S S S S S S , Journal of the American Chemical (2020) DOI: 10.1021/jacs.9b13100