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▎The content team editor of WuXi AppTec.
As early as about 20 years ago, people observed that antihypertensive drugs might be beneficial for reducing the risk of dementia or cognitive impairment.
Since then, relevant evidence has continued to accumulate, which not only confirms that the occurrence of hypertension may accelerate the decline of cognitive function, and that antihypertensive drugs can improve the blood supply to the brain’s memory center; it also confirms that patients with Alzheimer’s disease have their brains many years ago.
Pathological changes have appeared in the blood vessels.
Another recent study showed that a few years before the first symptoms of cardiovascular disease and cognitive impairment, there was a link between brain metabolism and cardiovascular disease risk factors and atherosclerosis.
Research has also shown that interventions on a modifiable cardiovascular risk factor may prevent the development of dementia, although there is currently no cure for dementia.
Screenshot source: JACC This important study was published in the Journal of the American College of Cardiology (JACC), and was carried out in collaboration with neuroimaging experts from the Spanish National Cardiovascular Research Center (CNIC) and the Barcelona Betaeta Brain Research Center (BBRC).
This study included a total of 547 middle-aged subjects (average age 50 years), these subjects have evidence of atherosclerosis, but asymptomatic, belong to subclinical atherosclerosis.
The researchers conducted a detailed cardiovascular and cerebrovascular assessment of the subjects, and used 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) to quantify the subjects’ brain metabolism, and then assessed subclinical atherosclerosis The relationship between sclerosis and brain metabolism.
▲ The 30-year Framingham Heart Risk Score (30-year FRS), hypertension, and carotid plaque are associated with decreased brain metabolism in middle-aged asymptomatic individuals.
The color indicates the strength of the association (yellow is a strong association; red is a low association).
The 30-year FRS is used to assess the risk of cardiovascular risk factors (such as age, smoking history, blood pressure, blood lipids, and blood sugar).(Image source: Reference [1]) Studies have shown that among asymptomatic middle-aged people, assessed by the 30-year Framingham heart risk score, cardiovascular risk factors are related to low brain metabolism, and hypertension shows the strongest association .
Even after adjusting for 30 years of FRS, the burden of carotid artery plaque is also related to the low level of global brain metabolism.
In other words, in the first few years without any clinical symptoms, atherosclerosis and cardiovascular risk factors have been shown to have an impact on brain metabolic health.
The study’s first author, Dr.
Marta Cortés Canteli, explained: “When the brain’s metabolism declines, the brain’s ability to process events is impaired.
Depending on the brain area affected, this can cause a range of different problems.
” The study Dr.
Juan Domingo Gispert, head of the neuroimaging team, pointed out: “In subjects with higher cardiovascular risk factors, the brain regions exhibiting low metabolism are the same as those affected by Alzheimer’s disease, indicating that these people may be more likely to suffer.
This disease.
" Neurodegenerative diseases and vascular diseases often occur at the same time, and recent studies have found that cognitive decline and some cardiovascular risk factors (including high blood pressure, obesity, and high cholesterol) are closely related.
Link.
The corresponding author of the study, Dr.
Valentín Fuster from CNIC and Mount Sinai Hospital, said: “Although everyone knows that controlling cardiovascular risk factors is important to prevent myocardial infarction, these same risk factors are also associated with cognitive decline, so this study The results may promote people’s awareness of starting to develop healthy habits early in life.
"Image source: 123RF study results provide more support for the importance of implementing major cardiovascular prevention strategies in middle-aged people.
This is a kind of Valuable methods can slow down or even prevent brain changes that may lead to future decline in cognitive function.
Dr.
Juan Domingo Gispert pointed out: "There is a lot of evidence that cardiovascular risk factors are related to Alzheimer's disease.If we can gain a more accurate understanding of this relationship during the asymptomatic stage of the disease, we will be able to design new strategies to prevent Alzheimer's disease.
"According to the author, this study is the largest study ever conducted in a healthy middle-aged population.
Dr.
Cortés Canteli said: "The next step is to determine that at the age of 50, subclinical atherosclerosis and low brain metabolism Of the population will continue to decline in cognitive ability after 10 years.
"Related reading The latest research reminds that it’s useless to be young! As long as blood pressure is high, it may accelerate cognitive decline.
JAMA's 100,000 data reconfirmed that blood pressure control can reduce dementia or cognitive impairment.
Alzheimer’s disease new hope: blood pressure reduction Medicine can improve the blood supply to the memory center of the brain [1] Cortes-Canteli,M.
, Gispert, JD, Salvadó, G.
, Toribio-Fernandez, R.
, Tristão-Pereira, C.
,Falcon, C.
, .
.
.
& Fuster, V.
(2021).
Subclinical atherosclerosis and brainmetabolism in middle-aged individuals: the PESA study.
Journal of the American College of Cardiology, 77(7), 888-898.
[2] Scientistsuncover early links between cardiovascular risk and brain metabolism, Reverted Feb 15, 2021.
from https://medicalxpress.
com/news/2021-02-scientists-uncover-early-links-cardiovascular.
html Note: This article aims to introduce medical and health research progress, not a treatment plan recommendation .
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
As early as about 20 years ago, people observed that antihypertensive drugs might be beneficial for reducing the risk of dementia or cognitive impairment.
Since then, relevant evidence has continued to accumulate, which not only confirms that the occurrence of hypertension may accelerate the decline of cognitive function, and that antihypertensive drugs can improve the blood supply to the brain’s memory center; it also confirms that patients with Alzheimer’s disease have their brains many years ago.
Pathological changes have appeared in the blood vessels.
Another recent study showed that a few years before the first symptoms of cardiovascular disease and cognitive impairment, there was a link between brain metabolism and cardiovascular disease risk factors and atherosclerosis.
Research has also shown that interventions on a modifiable cardiovascular risk factor may prevent the development of dementia, although there is currently no cure for dementia.
Screenshot source: JACC This important study was published in the Journal of the American College of Cardiology (JACC), and was carried out in collaboration with neuroimaging experts from the Spanish National Cardiovascular Research Center (CNIC) and the Barcelona Betaeta Brain Research Center (BBRC).
This study included a total of 547 middle-aged subjects (average age 50 years), these subjects have evidence of atherosclerosis, but asymptomatic, belong to subclinical atherosclerosis.
The researchers conducted a detailed cardiovascular and cerebrovascular assessment of the subjects, and used 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) to quantify the subjects’ brain metabolism, and then assessed subclinical atherosclerosis The relationship between sclerosis and brain metabolism.
▲ The 30-year Framingham Heart Risk Score (30-year FRS), hypertension, and carotid plaque are associated with decreased brain metabolism in middle-aged asymptomatic individuals.
The color indicates the strength of the association (yellow is a strong association; red is a low association).
The 30-year FRS is used to assess the risk of cardiovascular risk factors (such as age, smoking history, blood pressure, blood lipids, and blood sugar).(Image source: Reference [1]) Studies have shown that among asymptomatic middle-aged people, assessed by the 30-year Framingham heart risk score, cardiovascular risk factors are related to low brain metabolism, and hypertension shows the strongest association .
Even after adjusting for 30 years of FRS, the burden of carotid artery plaque is also related to the low level of global brain metabolism.
In other words, in the first few years without any clinical symptoms, atherosclerosis and cardiovascular risk factors have been shown to have an impact on brain metabolic health.
The study’s first author, Dr.
Marta Cortés Canteli, explained: “When the brain’s metabolism declines, the brain’s ability to process events is impaired.
Depending on the brain area affected, this can cause a range of different problems.
” The study Dr.
Juan Domingo Gispert, head of the neuroimaging team, pointed out: “In subjects with higher cardiovascular risk factors, the brain regions exhibiting low metabolism are the same as those affected by Alzheimer’s disease, indicating that these people may be more likely to suffer.
This disease.
" Neurodegenerative diseases and vascular diseases often occur at the same time, and recent studies have found that cognitive decline and some cardiovascular risk factors (including high blood pressure, obesity, and high cholesterol) are closely related.
Link.
The corresponding author of the study, Dr.
Valentín Fuster from CNIC and Mount Sinai Hospital, said: “Although everyone knows that controlling cardiovascular risk factors is important to prevent myocardial infarction, these same risk factors are also associated with cognitive decline, so this study The results may promote people’s awareness of starting to develop healthy habits early in life.
"Image source: 123RF study results provide more support for the importance of implementing major cardiovascular prevention strategies in middle-aged people.
This is a kind of Valuable methods can slow down or even prevent brain changes that may lead to future decline in cognitive function.
Dr.
Juan Domingo Gispert pointed out: "There is a lot of evidence that cardiovascular risk factors are related to Alzheimer's disease.If we can gain a more accurate understanding of this relationship during the asymptomatic stage of the disease, we will be able to design new strategies to prevent Alzheimer's disease.
"According to the author, this study is the largest study ever conducted in a healthy middle-aged population.
Dr.
Cortés Canteli said: "The next step is to determine that at the age of 50, subclinical atherosclerosis and low brain metabolism Of the population will continue to decline in cognitive ability after 10 years.
"Related reading The latest research reminds that it’s useless to be young! As long as blood pressure is high, it may accelerate cognitive decline.
JAMA's 100,000 data reconfirmed that blood pressure control can reduce dementia or cognitive impairment.
Alzheimer’s disease new hope: blood pressure reduction Medicine can improve the blood supply to the memory center of the brain [1] Cortes-Canteli,M.
, Gispert, JD, Salvadó, G.
, Toribio-Fernandez, R.
, Tristão-Pereira, C.
,Falcon, C.
, .
.
.
& Fuster, V.
(2021).
Subclinical atherosclerosis and brainmetabolism in middle-aged individuals: the PESA study.
Journal of the American College of Cardiology, 77(7), 888-898.
[2] Scientistsuncover early links between cardiovascular risk and brain metabolism, Reverted Feb 15, 2021.
from https://medicalxpress.
com/news/2021-02-scientists-uncover-early-links-cardiovascular.
html Note: This article aims to introduce medical and health research progress, not a treatment plan recommendation .
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
