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J Urol: Does androgen blocking therapy cause dementia?

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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Androgen block therapy (ADT) is mainly used for patients with metastatic prostate cancer, and the time for disease control is an average of 18 to 24 months
.

ADT can be used in combination with local treatments (such as radiotherapy) for high-risk local diseases or adjuvant treatments after radical prostatectomy, and has demonstrated its survival benefits

Diagnostic Although ADT provides an effective cancer control, but ADT to heart blood vessels , cognitive, metabolic and musculoskeletal health may have long-term effects despite ADT provides an effective cancer control, but ADT to heart blood vessels , cognitive, metabolic and muscle Bone health may have long-term effects on blood vessels

The relationship between androgen-blocking therapy (ADT) and prostate cancer male dementia is still inconclusive
.

Recently, researchers from the United States published an article in "J Urol".

A national longitudinal registry of prostate cancer patients assessed the relationship between cumulative ADT exposure and the onset of dementia.

The study included men ≥50 years of age in the registry
.

The main result is the condition of dementia after treatment

Of the 13,570 men, 317 (2.
3%) were diagnosed with dementia after a median follow-up of 7.
0 years (IQR 3.
0-12.
0)
.

The cumulative use of ADT was significantly associated with dementia (HR 2.

Correlation between cumulative ADT exposure and incidence of dementia

In summary, cumulative ADT exposure is related to the incidence of dementia
.

Therefore, for those patients who need to receive ADT treatment, their needs and treatment benefits should be carefully considered

Cumulative ADT exposure is related to the incidence of dementia Cumulative ADT exposure is related to the incidence of dementia

Original source:

Peter E Lonergan, Samuel L Washington 3rd, Janet E Cowan et al.

Androgen Deprivation Therapy and the Risk of Dementia after Treatment for Prostate Cancer

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