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J Urol: 18F-DCFPyL-PET/CT can accurately detect and locate the metastases of prostate cancer

 Last Update: 2021-03-20
 Source: Internet
 Author: User

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The current conventional imaging methods, including enhanced CT, MRI, and 99mTc-methylene bisphosphonate (MDP) bone imaging, are not ideal methods for detecting metastatic sites of metastatic prostate cancer (PCa) in different states.

OSPREY is a prospective trial designed to determine the diagnostic performance of 18F-DCFPyL-PET/CT in detecting metastatic prostate cancer .

It intended to identify 18F-DCFPyL-PET / CT in the detection of metastatic prostate cancer site diagnostic performance aimed at determining 18F-DCFPyL-PET / CT in the detection of metastatic prostate cancer site diagnosis performance diagnostic

Two groups of patients underwent 18F-DCFPyL-PET/CT examination: Group A included high-risk PCa patients who underwent radical prostatectomy and pelvic lymphadenectomy; Group B included pre-PCa patients who were suspected of recurrence/metastasis by routine imaging examination.

A total of 385 patients were included.

In group A (252 evaluable subjects), the median specificity of 18F-DCFPyL-PET/CT in detecting pelvic lymph node metastasis was 97.

In group B (n=93, median PSA was 11.

The specificity of PSMA-targeted PET/CT to detect metastatic prostate cancer reached the predetermined primary endpoint, but the sensitivity did not.

Original source:

Pienta Kenneth J, Gorin Michael A, Rowe Steven P et al.

org/10.
1097/JU.
0000000000001698" target="_blank" rel="noopener">A Phase 2/3 Prospective Multicenter Study of the Diagnostic Accuracy of Prostate-Specific Membrane Antigen PET / CT with 18F-DCFPyL in Prostate Cancer Patients (OSPREY) in this message

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