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J Thromb Haemost: The incidence of hemophagocytic lymphohistiocytosis in adults and the incidence of thromboembolism and its impact on overall survival

 Last Update: 2021-12-24
 Source: Internet
 Author: User

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Hemophagocytic lymphohistiocytosis is a rare syndrome characterized by uncontrolled immune system activation and a higher risk of death
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There are few data on the incidence of bleeding and thromboembolism in patients with hemophagocytic lymphohistiocytosis

Immune Thrombosis

Recently, a research article was published in the Journal of Thrombosis and Haemostasis, the authoritative journal of thrombosis and coagulation diseases, which aims to determine the cumulative incidence of hemophagocytic lymphohistiocytosis in adults and thromboembolism and its impact on patient survival.
Influence
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Researchers conducted a multicenter retrospective cohort study of adults with hemophagocytic lymphohistiocytosis in Alberta, Canada (1999-2019)
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The researchers calculated the cumulative incidence of bleeding and thromboembolism in the subjects, and considered the risk of competition

Researchers identified 97 adults with hemophagocytic lymphohistiocytosis (median age 46 years)
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Eleven (11%) patients developed venous thromboembolism (VTE) at a median time of 9 days after admission

Thus, in adults with hemophagocytic lymphohistiocytosis, VTE appears to be more common than previously described and is a predictor of patient death, although this may be due to unadjusted confounding factors
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Due to the high bleeding rate, the prevention and treatment of VTE is challenging

In adults with hemophagocytic lymphohistiocytosis, VTE appears to be more common than previously described and is a predictor of patient death, although this may be due to unadjusted confounding factors

Original Source: Incidence of Bleeding and thromboembolism and Impact ON Overall Survival in Adult patients with hemophagocytic lymphohistiocytosis: A 20-year Provincial Retrospective cohort Study in this message

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