 Home > Active Ingredient News > Antitumor Therapy > J Thorac Oncol: Comparison of the efficacy of RovalPituzumab tesiine and topotecan as second-line treatment options for small cell lung cancer

J Thorac Oncol: Comparison of the efficacy of RovalPituzumab tesiine and topotecan as second-line treatment options for small cell lung cancer

 Last Update: 2021-03-20
 Source: Internet
 Author: User

Tags

portable high frequency

small glass tubes

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Delta-like protein 3 (DLL3) is an atypical Notch ligand that is expressed in small cell lung cancer (SCLC) tumors and cannot be detected in normal adult tissues.

TAHOE is an open-label randomized phase 3 study designed to compare the efficacy and safety of Rova-T and topotecan as a second-line treatment for advanced or metastatic small cell lung cancer with high DLL3 expression.

The aim was to compare the efficacy and safety of Rova-T and topotecan as a second-line treatment for advanced or metastatic small cell lung cancer with high DLL3 expression.

The test patients were randomly divided into two groups according to 2:1, and they received Rova-T (0.

A total of 444 patients were recruited: 296 in the Rova-T group and 148 in the topotecan group.

Overall survival rate of the two groups

Progression-free survival rate of the two groups

The median OS (95%CI) of the Rova-T group and topotecan group were 6.

Compared with the current standard second-line chemotherapy regimen topotecan, Rova-T shows poorer OS in patients with small cell lung cancer, and has a higher incidence of serous cavity effusion, photosensitivity and peripheral edema.

Original source:

Blackhall Fiona, Jao Kevin, Greillier Laurent et al.

org/10.
1016/j.
jtho.
2021.
02.
009">Efficacy and Safety of Rovalpituzumab Tesirine Compared with Topotecan as Second-Line Therapy in DLL3-High Small Cell Lung Cancer: Results from the Phase 3 TAHOE Study in this message

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

Crocetin27876-94-4

CAS No.: 27876-94-4

$1-1.1/G FOB

Betulinic acid472-15-1

CAS No.: 472-15-1

$1-1.1/G FOB

1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane 53-19-0

CAS No.: 53-19-0

Pharmacy Grade

$100/KG EXW

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.