J Rheumatol: The Challenge of Very Early Systemic Sclerosis: A Mix of Mild and Early Diseases?

In order to address the hypothesis that very early systemic sclerosis (SSc) is a group of mild or early patients with heterogeneousness, the degree of heterogeneity in clinical, epidemiological, and immunological characteristics of these patients is analyzed herestudies analyzed very early SSc patients from The Zurich Queue who did not meet the 2013 ACR/EULAR standard sesame and did not meet the 1980 ACR classification criteria, but were clinically diagnosed as SSc, with Reynolds and other characteristics of SSc (finger swelling, SSc-specific antibodies, SSc type on the capillary vascular mirror, or any of the organ characteristics of Sc)The duration of the disease is defined from the first Reynolds symptom102 patients met the criteria and analyzed themTheir clinical manifestations are heterogeneous, with most manifestations of renophenomenonos, ANA antibodies, and methicical capillary changes, but others are different, such as SSc-specific antibodies and early signs of organ fatigueAlthough 54.1% of patients (52/96) had less than 5 years of disease, as many as 29.1% (28/96) had a course greater than 10 years, indicating the long-term presence of mild illnessIn terms of initial visits, there was no difference in clinical characteristics between patients with very early stage disease and patients with long-term and mild diseasesthis study showed that patients with very early SSc were a mixture of mild or early-stage patientsThis needs to be considered in clinical practice for risk stratification and research design for patients considered to be early Ssc