J Rheumatol: Liver abnormalities in patients with psoriasis arthritis

The purpose of this study was to determine the prevalence and incidence of liver abnormalities in patients with psoriasis arthritis (PsA) and to identify the factors associated with itresearchers identified PsA patients (case groups) whohad elevated serum transaminase or alkaline phosphatase levels or developed liver disease after the first visit to the PsA clinicThe control group was from subjects in the same queue, but never had such abnormalities or liver diseaseCases and controls were paired in a 1:1 ratio based on sex, age of initial visit and follow-up time, and variables were used to determine the first liver abnormality associated with liver abnormalities using single-factor logistic and multi-factor logistic regression analysis343 of the 1,061 patients followed by the PsA clinic had liver abnormalitiesTwenty-six patients with liver abnormalities after the first visit were identified as case groups, while 718 patients were identified as control groupsThe prevalence of liver abnormalities was 32%, with a incidence rate of 39/1000 patients - 6533 patients in PsA coin - 256 patients in the yearOn average (SD) follow-up was 8.3 to 7.8 years after liver abnormalities were detectedCommon causes of liver abnormalities are drug-based hepatitis and fatty liver diseaseIndependent factors associated with liver abnormalities are high body mass index (BMI), daily alcohol consumption, high number of joint injuries, elevated C-reactive protein, and the use of methotrexate, leflunomide, or tumor necrosis inhibitorsliver abnormalities are common in PsA patients and are associated with elevated BMI, more severe disease, and certain treatments