J Rheumatol: Kidney Resistance Index, a new biomarker for vascular change in follow-up systemic sclerosis
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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This retrospective observation study is designed to assess SSc diseaseChanges in the kidney resistance index (RRI) over time and during treatment and associated with complications of the diseaserecruited 230 patients (29 males, median age 57 years (48-67))At baseline and follow-up , the following data were collected: disease indicators, capillary oscopyos (NVC) types, FVC (force lung capacity), co2 dispersion capacity (DLCO), systolic pulmonary arterial pressure (sPAP), interstitial pulmonary disease, RRI, and glomerular filtration (eGFR) assessment, new pulmonary hypertension (pH) assessmenthad higher RRI values in SSC patients with finger-end ulcers and ACA antibodies, active and advanced NVC types, and lcSScIn patients with concurrent PAH, a significant correlation was observed between the rRRI and the sPAP (r?0.17, p.02) and a significant increase in the rRRI (0.08?0.02 vs 0.03-0.05, p-0.04)No other new complications are associated with rRRIThe ROC curve analysis confirms the predictive effect of the rRRI in the occurrence of the new PAH (AUC 0.84; 95% CI 0.75-0.93, p-0.02)Compared to patients who used sidinaina during the study period (0.01 to 0.05, p.03) or patients used in baseline assessment (0.00 to 0.05, p.01), the RR I was higher (0.04 s.05) in patients who had never used Sscinathan (0.04?0.05)RRI and its changes over time are reliable indicators of sSC-related vascular lesions in the kidneys and exoskeleton
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