J Parkinson dis: can fecal transplantation treat Parkinson's disease?

November 20, 2019 / Bio Valley bio on / -- constipation is a common disease in Parkinson's disease (PD) patients Fecal microbiome transplantation (FMT) and probiotics and probiotics are potential options for the treatment of constipation and recovery of Parkinson's disease (PD) patients However, scientists believe that due to the lack of clinical data, more research is needed before clinical use They presented their findings in a review article in Journal of Parkinson's disease In this review, the researchers evaluated the progress of studies on the use of fecal transplantation and probiotics to restore normal intestinal microbial balance in PD patients, and highlighted the questions that still need to be answered (image source: www Pixabay Com) fecal transplantation includes the transfer of liquid filtrate feces from healthy screened individuals to patients through a nasogastric or nasoduodenal tube, enema, or colonoscopy "Fecal transplantation is an interesting option to restore the homeostasis of the microbiome in PD patients," explained lead researcher Dr TEUs van Laar, head of the Department of Neurology at the University of Groningen medical center This is an attractive technique because administration is relatively simple and usually has only minor adverse reactions However, at present, there is no strict clinical trial for this treatment, and there is no systematic understanding of the optimal content of fecal transplantation, the way of administration and the long-term impact " Many studies have repeatedly proved that Lactobacillus and Bifidobacterium can effectively treat constipation of PD within 4-12 weeks However, there is no reliable clinical data on the possible effects of these probiotic treatments on motor symptoms or PD progression After encouraging results from probiotics in animal studies, Ghent University is conducting the first clinical trial on the treatment of PD patients with fecal transplantation, which is scheduled to be completed by the end of 2019 The researchers plan to recruit 40 PD patients and follow them up for three months at intervals of up to one year The trial will assess the development of PD symptoms The data parameters analyzed in the clinical trial did not include or exclude constipation related information, which may complicate the interpretation of the results, the researchers noted The researchers suggest that patients with PD should wait for better clinical data before choosing the right target population and predicting the expected clinical effect Source of information: Federal transformation to treat patients with Parkinson's disease: hope or hype? Original source: T van Laar, J.M boertien, A Horta herraz Financial transformation, pro - and prebiotics in Parkinson's disease; hope or hype? Journal of Parkinson's disease, 2019; 9 (S2): s371 doi: 10.3233/jpd-191802