J Neurosci: taking a ketone diet may help the body resist Alzheimer's disease

December 13, 2019 / BIOON / -- recently, a report published in the International Journal of neuroscience entitled "SIRT3 haploinsufficiency initiatives loss of GABAergic interneurons and neural network hyperactivity in an Alzheimer's disease" In the model study, researchers from institutes such as the National Institutes of health found that a diet supplemented with ketones could protect brain neurons from death during the progression of Alzheimer's disease Photo source: Cheng et al., jneurosci 2019 When in the early stage of Alzheimer's disease, the brain usually becomes over excited, which may be realized by the loss of inhibitory or GABAergic intermediate neurons, which can prevent other neurons from sending too much signals Compared with other neurons, intermediate neurons often need more energy When they encounter Alzheimer's disease protein - β - amyloid protein, these intermediate neurons will become very easy to die β - amyloid protein will damage the cell's energy factory - mitochondria by interfering with the function of SIRT3 protein SIRT3 protein can protect the function of mitochondria and protect neurons from damage Damage In this study, the researchers inherited It can reduce the SIRT3 protein level in the Alzheimer's disease mice model Compared with the standardized Alzheimer's disease mice model and the control mice, the mice with lower SIRT3 protein level often experience higher mortality, more severe seizures and higher mortality of intermediate neurons However, when they eat a diet rich in ketones (ketones are a special category Low SIRT3 mice will experience fewer epileptic seizures and will not die easily This diet may increase the level of SIRT3 in mice Finally, the researchers suggest that increasing SIRT3 levels through ketone intake may be a special way to protect the survival of brain interneurons and effectively slow down the progress of Alzheimer's disease Original sources: Aiwu Cheng, Jing Wang, Nathaniel ghena, et al SIRT3 haploinsufficiency agencies loss of GABAergic interneurons and neural network hyperefficiency in an Alzheimer's disease model, jneurosci (2019) Doi: 10.1523/jneurosci.1446-19.2019