J Neurol Neurosur Ps: Father takes anti-epileptic drugs and child outcomes.

!---- recently published a study in Journal Of, an authoritative journal of neurology, that looked at the association between fathers using anti-epileptic drugs (AEd) and adverse neurodevelopmental outcomes and major congenital malformations (MCM) in future generationsresearchers identified 114,795 children of 74,1726 fathers without epilepsy and 4,544 children of 2,955 fathers without epilepsy using the Swedish National Registry2,087 (45.9%) of them were born to epileptic fathers who had taken AED during pregnancychildren whose parents have epilepsy are excludedresearchers analyzed the incidence of MCM in children, autism disorder, attention deficit hyperactivity disorder (ADHD), and intellectual disabilitychildren born to fathers with epilepsy who did not take AED, children of fathers who took AED, MCM (corrected OR 0.9, 95% CI 0.7 to 1.2), autism (corrected HR (aHR) 0.9, 95% The risk of ADHD (aHR 1.1, 95% CI is 0.7 to 1.9) or intellectual disability (aHR is 1.3 and 95% CI is 0.6 to 2.8) did not increasethe incidence of autism (2.9/1000 children-years) and intellectual disabilities (1.4/1000 children-years) in children born to epileptic fathers who used valproate for monotherapy during conception was slightly higher than during conception Children born to fathers of epilepsy who did not take AED (2.1/1000 children-years for autism, 0.9/1000 years for intellectual disabilities- years), but there was a statistically significant increase in the risk of not seeing adverse outcomes in the tendentious scoring adjustment analysisit shows that fathers taking AED during pregnancy have nothing to do with their child's bad outcomes.