J Med Virol: novel coronavirus genome sequence characteristics revealed by the largest meta-analysis

The novel coronavirus (2019-nCoV) genome has been analyzed by the largest sequencing analysis in February 9, 2020 / Biovalley BIOON/ The results showed that the virus originated from bats and the heterogeneity of viruses was low Recently, a virus was published in the International Journal Journal of Medical Virology In the previous report, scientists from the University of Bologna identified a highly variable genomic hotspot region in the virus protein, which is mainly related to the existence of two virus subtypes Source: novel coronavirus has infected 28276 individuals, 565 of them have died, so far, the researchers reported on the genome of 56 coronavirus from around the world, including Lazzaro from Rome, Italy, according to University of Bologna China's novel coronavirus genome is the most widely studied and studied genome of two Chinese patients in the Spallanzani infectious disease ward The researchers say the virus may have originated from a zoonotic pathogen, and their closest relatives have only recently been isolated by researchers, that is, EPI ISL, a coronavirus sequence found in a Rhinolophus in Yunnan Province, China 402131 matched; the novel coronavirus genome of humans has at least 96.2% similarities with bat relatives, while the similarity with SARS is only 80.3% The researchers found that at present, the DNA sequences of all coronaviruses are very similar Even though they come from different regions of China and all over the world, since the outbreak of the epidemic, more than 99% of the genome sequences of the viruses isolated by the researchers from the patients have the same sequence, which shows that the virus shows low heterogeneity and variability, which seems to be The good news is that potential therapeutic drugs are thought to be more effective for everyone because of the same kind of virus However, in this study, researchers identified a highly variable hot spot area in virus protein for the first time, and finally identified two virus subtypes The difference between them is only one amino acid, which can change the sequence and structure of ORF8 coding protein ORF8 coding protein is a virus component that has not been identified Original source: carmine ceraolo, Federico M Giorgi Genetic variation of the 2019 - ncov coronavirus, Journal of Medical Virology (2020) Doi: 10.1002/jmv.25700