J Korean Med Sci: In Korean children between 6 and 35 months of age, immunity declined six months after the triple and four-price flu vaccinations.

Antibody titration caused by influenza vaccines decreases over time, and younger children have lower immunogenicity and shorter immunization times.
this study aims to compare the persistence of antibodies in children 6 to 35 months after being vaccinated against influenza, based on influenza strains, vaccine types, antigen doses, and initial status, and has been published online in J Korean Med Sci.
From September to December 2016, researchers selected 124 healthy children between 6 and 35 months of age at 10 hospitals in South Korea and randomly assigned a full dose of the four-price flu vaccine or a half-dose of the Victoria B strain triple-price influenza vaccine.
blood clot inhibits antibody titration (a measure of serum protection rate) of recommended influenza strains 6 months after vaccination.
results showed that the serum protection rates of A(H1N1, H3N2, B) and B Victoria were 88.7%, 97.4%, 36.6% and 27.6%, respectively, after six months. Serum protection rates of
A (H1N1), A (H3N2) and B (Victoria) were 91.4 per cent, 98.7 per cent and 27.5 per cent in full-dose four-price vaccines, respectively, and 83.7 per cent, 94.6 per cent and 27.9 per cent in half-dose trialose vaccines, respectively.
protection rate of B (mountain) strains in the four-price group was 23.8%, and the three-price group was 14.0%.
, the results show that after 6 months, the persistence of antibodies is more beneficial to influenza A strains than to influenza B strains.
four-pyr price vaccine group was more persistent against additional B strains at 6 months.
children who were vaccinated against different B strains were no better immune than those who were not vaccinated against another B strain.
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