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J Invest Dermatol: Impaired autophagy in psoriasis and atopic dermatitis: a new therapeutic target?

 Last Update: 2021-11-03
 Source: Internet
 Author: User

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Autophagy is an important biological process, which involves intracellular quality control, metabolism and cell survival , enabling cells to recover cytoplasmic material under stress conditions

Quality control of the cell metabolism and cell survival development, innate immunity, antigen presentation and lymphocyte antigen receptor signal transmission

AD and psoriasis biopsies and KCs TNF treated with long-term showed P accumulated 62 / SQSTM1, it is usually degraded autophagic process, indicating that despite the increased formation of autophagic body, but the waste is processed by the Hinder

Decreased expression of cathepsin D and L may be the cause of psoriatic hypokeratosis.

Autophagy in immunization another prominent feature is the inhibition of the synthesis of proinflammatory cytokines, including IL-1 in the synthesis of type I interferon

Other functions mediated by autophagy may not be conducive to the treatment of skin-related autoimmune diseases

KCs hyperplasia is another feature of psoriasis TCR stimulation increases autophagy, and the lack of regulatory factor substantially autophagy mouse thymocytes and the CD .

Figure: In inflammatory skin diseases, TNF-α mediates the damage of keratinocyte autophagy

Original source:

Hailfinger S, Schulze-Osthoff K,Impaired Autophagy in Psoriasis and Atopic Dermatitis: A New Therapeutic Target?J Invest Dermatol 2021 Sep 23

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