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J Immunother Cancer: Safety and effectiveness of immune checkpoint inhibitors in patients with previous psoriasis

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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Immune checkpoint inhibitors (ICIS) block inhibitory T cell receptors and promote enhanced anti-tumor activity
.

These drugs, especially antibodies against CTLA-4, PD-1 and PD-L1 , have changed cancer treatments and have been approved for 15 different cancers

, Has changed the method of cancer treatment, and has been approved for 15 different cancers

In this retrospective cohort study, patients with previous psoriasis from 8 academic centers were evaluated and these patients received ICI for cancer

In this multicenter study, ICI treatment was associated with frequent exacerbations of psoriasis, and the onset of psoriasis could be controlled by standard psoriasis treatment, and ICI was rarely discontinued
.

Therefore, patients with a history of psoriasis can receive ICI for malignant tumors

Patients with a history of psoriasis can receive ICI for malignant tumors

Literature source: Halle BR, Betof Warner A, Zaman FY, Immune checkpoint inhibitors in patients with pre-existing psoriasis: safety and efficacy.

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