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J Immunother Cancer: Nanoencapsulated rituximab mediates excellent cellular immunity against metastatic B-cell lymphoma in a humanized mouse model with complement activity

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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vitamin cancer

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Therapeutic monoclonal antibodies (mAbs), such as anti-CD20 rituximab (RTX) for non-Hodgkin's lymphoma (NHL) and trastuzumab/herceptin for breast cancer (anti-Her2) change the tradition The way of cancer treatment has revolutionized cancer treatment.

In order to create a favorable system successfully implanted human cells, the lack of a common cytokine receptor γ chain (IL- 2Rγ) advanced immunodeficiency NOD.

Lack of common cytokine receptor γ chain (IL- 2Rγ) advanced immunodeficiency NOD.

In this study, a new strain of NSG established a humanized mouse model, i.

^-Hc1Prkdc ^SCID^-Hc1

The results of the study are as expected.

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In summary, NSG- ^Hc1 mice can be used as a viable model, which can be used to study the use of cancer-targeted anti-tumor therapies, and to understand the induction mechanism of anti-tumor cell immune responses.

NSG- ^Hc1 mice can be used as a viable model, which can be used to study the use of cancer-targeted anti-tumor therapies, and to understand the induction mechanism of anti-tumor cell immune responses.
^-Hc1WenJ ,WangL ,RenJ WenJ Wen WangL Wang RenJ Ren , et al.
bmj.
com/content/9/2/e001524" target="_blank" rel="noopener">Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model.
Journal for ImmunoTherapy of Cancer 2021; 9: e001524.
doi: 10.
1136/jitc-2020-001524 doi: leave a message here

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