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J Immunother Cancer: Bempegaldesleukin combined with nivolumab in first-line treatment of advanced renal cell carcinoma

 Last Update: 2022-05-20
 Source: Internet
 Author: User

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Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has dramatically changed the treatment landscape for patients with advanced renal cell carcinoma (RCC)

The aim of this study was to evaluate the efficacy and safety of the immunostimulatory interleukin-2 cytokine prodrug Bempegaldesleukin (BEMPEG) in combination with nivolumab (NIVO) as first-line therapy in patients with advanced clear cell renal cell carcinoma

This is an open-label, multicohort, multicenter, single-arm, phase 1/2 study; this paper reports results from a phase 1/2 first-line RCC cohort (n=49)

The primary endpoints were objective response rate (ORR) and safety

The objective response rate was 34.

In patients with advanced clear cell renal cell carcinoma , BEMPEG combined with nivolumab as first-line therapy showed preliminary antitumor activity and was well tolerated Treatment regimen showed preliminary antitumor activity and was well tolerated

Original source:

Tannir Nizar M, Cho Daniel C, Diab Adi et al.

Tannir Nizar M, Cho Daniel C, Diab Adi et al.
Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study.
[J] .
J Immunother Cancer, 2022, 10: https://doi.
org/10.
1136/jitc-2021-004419.

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