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J Immunother Cancer: Antibiotics have a significant negative effect on the prognosis of NSCLC patients treated with pembrolizumab!

 Last Update: 2021-04-16
 Source: Internet
 Author: User

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In unselected patients with non-small cell lung cancer ( NSCLC ) , some concomitant drugs , including antibiotics (ATB), are related to poor survival of immune checkpoint inhibitor (ICI) treatment, and the correlation is reproducible .

An article published recently in " J Immunother Cancer " of " Journal of Cancer Immunotherapy " outlines a large-scale study of patients with metastatic NSCLC who received first-line pembrolizumab monotherapy with PD-L1 expression of ≥50%.

J Immunother Cancer J Immunother Cancer

The pembrolizumab and chemotherapy cohorts included 950 and 595 patients, respectively.

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Overall survival analysis

In multivariate analysis, ATB can be used as a strong predictor of poor overall survival (OS) and progression-free survival (PFS) in the pembrolizumab group (HR is 1.

ATB can be used as a strong predictor of poor overall survival (OS) and progression-free survival (PFS) in the pembrolizumab group (HR 1.

Progression-free survival analysis

Corticosteroids after pembrolizumab treatment or chemotherapy were associated with shorter PFS (HR 1.

In summary, this study proved that ATB has a significant negative effect on the prognosis of NSCLC patients with pembrolizumab monotherapy , but it has no significant effect on chemotherapy, which further proves the potential immunomodulatory effect between them.

ATB has a significant negative effect on the prognosis of NSCLC patients with pembrolizumab monotherapy.

Original source:

Cortellini A, Di Maio M, Nigro O, et al bmj.

bmj.
com/content/9/4/e002421" target="_blank" rel="noopener">Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapy

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