J Immunol: Proper regular exercise inhibits cell aging and tumor development

More and more cancer treatments are incorporating physical activity into care programs, and numerous studies have shown that exercise can reduce cancer risk, control disease progress, amplify the effectiveness of anti-cancer treatment, and improve physical function and psychosocial outcomes.
a new study published recently in the journal Immunology suggests that proper regular exercise can reduce inflammation in the liver and reverse liver damage and prevent the development of liver tumors. In the
study, researchers divided older mice with chronic inflammation into exercise groups (16) and sedent sedents (13), and exercise group mice were on a treadmill for 30 minutes at the same time three weeks (Monday, Wednesday, Friday) morning.
routine includes a 5-minute warm-up at 14 cm/s, a 20-minute jog at 20 cm/s and a 5-minute slow run at 14 cm/s.
group of mice did not exercise on the treadmill.
group of mice were restricted to where they grew in cages.
, two groups of mice were weighed and checked for physical condition.
results showed a significant reduction in the number of p21-positive liver cells and a decrease in the number of liver cells carrying damaged telomeres compared to sedenttic mice.
addition, lower levels of 4HNE staining show that exercise prevents lipid peroxidation caused by reactive oxygen, which is the basis for DNA damage in this model.
38.5% of mice in the sedentential group had tumors, while only one mouse in the exercise group had signs of tumor growth, and this anti-tumor effect decreased with a decrease in the number of PCNA plus and yH2AX plus liver cells.
exercise inhibits cell aging and tumor development It is well known that fat cell death occurs under a variety of pathophysiological conditions, including obesity and alcohol consumption, especially in the liver, where the death of large numbers of fat cells mainly leads to liver damage and inflammation.
further, even mice with advanced liver tumors showed that proper regular exercise reduced liver inflammation levels and improved metabolism in older mice compared to sedentary conditions.
same time, the exercised mice maintained physical activity during the aging process, an indicator of overall health, while the physical activity of the mice that did not exercise decreased significantly.
, epidemiological and intervention studies have shown that exercise, as part of a health-care plan, can improve quality of life and extend the life span of chronically ill people.
The findings suggest that even moderate-intensity exercise interventions are sufficient to prevent and alleviate metabolic diseases, reduce telomere DNA damage and cell aging, and promote the reversal of liver fat degeneration, the withdrawal of inflammation, and the prevention of liver tumors.