J Exp Med: Discover tumor indocendos! It is revealed that breast cancer cells achieve immune defense through local CCR2.

July 19, 2020 /PRNewswire/ -- Mikala Egeblad, an associate professor at Cold Spring Harbor Laboratory (CSHL), and her colleagues describe a new way for breast cancer cells to destroy key cells in the body's immune systemThis key cell provides local immune monitoring by activating the killer T cell, but if it does not mature and complete its work, breast cancer cells can escape detection by the immune system, leading to unnoticed and unobstructed growthThis key cell is a cross-presented dendritic cellThese cells are important because they initiate and coordinate local immune responses by showing cancer cell fragments to so-called killer T cellsThe killer T cells can then detect and destroy cancer cellsPhoto Credit: Xue-Yan He, Egeblad lab, CSHL scientists have found that breast cancer cells use an unexpected protein on their surface, known as cell surface receptor CCR2It destroys the maturation of cross-delivered dendritic cellsThis is surprising because CCR2 has a completely different function in immune cells, which use receptors to guide themselves into the inflammatory regionHowever, when CCR2 receptors appear on the surface of tumor cells, they inhibit the secretion signals needed for dendritic cells to matureResearchers are eager to know more precisely how cancer cells use CCR2 to suppress these key proteins, but the new study suggests that CCR2 itself can be a targetIn 2012, Egeblad's lab revealed that blocking CCR2 on immune cells can improve the drug's ability to penetrate tumorsNow, the drug that blocks CCR2 is being tested in clinical practice as a cancer therapyThese latest findings suggest that blocking the activity of CCR2 can also help the body's own immune response to fight cancerPostdoctoral researcher Miriam Fein added: "This study goes into the depths of what no one really thought about when it stopped CCR2It opens up new ideas for better therapies or the different ways in which existing drugs are usedReferences: Howbreast cancer cells pass past local immune defensesMiriam RFein et al, cancer cell ccR2 orchestrates seis eth no the adaptive immune response, The Sein of The DOI: 10.1084/jem.20181551.