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J Clin Oncol: Toripalimab combined with chemotherapy for the treatment of advanced non-small cell lung cancer

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Toripalimab is a specific human-derived IgG4K monoclonal antibody against human PD-1 that has a different domain

The CHOICE-01 study evaluated the efficacy and safety

465 patients with advanced NSCLC who did not carry the EGFR/ALK mutation were randomly divided into two groups and received 4 to 6 courses of chemotherapy with Toripalimab (240 mg, n=309) or placebo (1 beat/3 weeks) plus chemotherapy, followed by Toripalimab or placebo with standard of care maintenance

At the time of the final PFS analysis, PFS was significantly longer in the Toripalimab group than in the placebo group (median PFS: 8.

The incidence of grade 3 and above adverse reactions was similar

Together, the findings show that Toripalimab combined chemotherapy significantly improves PFS and OS in patients with untreated advanced NSCLC with controlled safety

Original Source:

Zhijie Wang, et al.

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