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J clin oncol: The influence of donor clonal hematopoiesis on the clinical prognosis of hematopoietic cell transplant recipients

 Last Update: 2021-12-01
 Source: Internet
 Author: User

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Clonal hematopoietic (CH) is an age-related asymptomatic disease.

In allogeneic hematopoietic cell transplantation, if the donor has clonal hematopoiesis, the recipient may obtain clonal hematopoiesis after hematopoietic cell transplantation

immunity

Researchers such as Christopher performed targeted error-correction sequencing on samples from 1727 bone marrow donors ≥40 years of age, and evaluated the impact of donor clonal hematopoiesis on the clinical outcome of recipients

22.

The correlation between DNMT3A-CH and the risk of receptor recurrence

In patients receiving calcineurin-based graft-versus-host disease prevention strategies, the donor DNMT3A-CH and the recipient had fewer recurrences (HR 0.

Prevention of donor DNMT3A-CH was associated with decreased recipient recurrence (HR 0.

The relationship between DNMT3A-CH and the risk of chronic graft-versus-host disease in the recipient

No single DNMT3A-CH or TET2-CH recipient has developed donor cell leukemia (DCL)

Among the 8 cases of DCL, 7 cases evolved from donor clonal hematopoietic donor cells carrying rare TP53 mutations or splicing factor mutations or donor cells carrying germline DDX41 mutations

Donor clonal hematopoiesis is closely related to the clinical prognosis of transplant recipients Donor clonal hematopoiesis is closely related to the clinical prognosis of transplant recipients

Original source:

Christopher J.

Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

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