 Home > Active Ingredient News > Antitumor Therapy > J Clin Oncol: Ripatinib vs sunitinib in the late-line treatment of advanced gastrointestinal stromal tumors

J Clin Oncol: Ripatinib vs sunitinib in the late-line treatment of advanced gastrointestinal stromal tumors

 Last Update: 2022-08-19
 Source: Internet
 Author: User

Tags

clinical omics

ritalin 36 mg

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Sunitinib is a multi-targeted tyrosine kinase inhibitor (TKI) approved for advanced gastrointestinal stromal tumors (GIST) that have failed imatinib therap.

The study aimed to compare the efficacy and safety of repatinib with sunitinib in patients with advanced GIST previously treated with imatini.

Imatinib-treated patients with advanced GIST were randomized (1:1) to ripatinib (150 mg, oral, 1/day) and sunitinib (50 mg, oral, 1/day), followed by 4 weeks on, 2 weeks off; and stratified according to KITI platelet-derived growth factor alpha mutation and imatinib toleranc.

Overall, a total of 453 patients were randomized to ripatinib (ITT: n=226; KIT exon 11 ITT: n=164) or sunitinib (ITT: n=227; KIT exon 11) Sub 11 ITT: n=164.

In the KIT exon 11 ITT population, the objective response rate was higher with ripatinib than with sunitinib (29% vs 16%, p=03.

In conclusion, ripatinib did not demonstrate superior properties to sunitinib in terms of progression-free survival in patients with advanced gastrointestinal stromal tumor.

Original source:

Sebastian Bauer, et a.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

Crocetin27876-94-4

CAS No.: 27876-94-4

$1-1.1/G FOB

Betulinic acid472-15-1

CAS No.: 472-15-1

$1-1.1/G FOB

1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane 53-19-0

CAS No.: 53-19-0

Pharmacy Grade

$100/KG EXW

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.