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J Clin Oncol: Phase 3 trial results of Andecaliximab combined with mFOLFOX6 as a first-line therapy for advanced gastric/gastroesophageal junction adenocarcinoma

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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Matrix metalloproteinase 9 is an extracellular enzyme involved in matrix remodeling, tumor growth and metastasis.

Andecaliximab (ADX) is a monoclonal antibody that can inhibit matrix metalloproteinase-9.

This study is a randomized, double-blind, placebo (PBO)-controlled multicenter Phase III study, which aims to evaluate mFOLFOX6 with or without ADX in the treatment of untreated human epidermal growth factor receptor 2 negative gastric cancer or GEJ glands Efficacy and safety of cancer.

Stomach cancer

Prognosis between treatment subgroups

From September 2015 to May 2017, 432 patients were randomized: 218 patients received ADX treatment, and 214 patients received PBO treatment.

The median OS of the ADX group and the PBO group were 12.

Prognosis of patients up to 65 years old

In the subgroup analysis, the OS and PFS of patients 65 years and older in the ADX group were also significantly better than those in the PBO group.

In summary, for unselected, untreated human epidermal growth factor receptor 2-negative gastric cancer or GEJ adenocarcinoma patients, the addition of ADX to the mFOLFOX6 regimen does not improve OS.

Original source:

Shah Manish A, Bodoky Gyorgy, Starodub Alexander et al.

org/doi/10.
1200/JCO.
20.
02755">Phase III Study to Evaluate Efficacy and Safety of Andecaliximab With mFOLFOX6 as First-Line Treatment in Patients With Advanced Gastric or GEJ Adenocarcinoma (GAMMA-1) in this message

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