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J Clin Oncol: Maintenance therapy with rucaparib after chemotherapy in DNA repair-deficient metastatic urothelial carcinoma

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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A subset of patients with metastatic urothelial carcinoma (mUC) have a DNA repair deficient (DRD) phenotype that predicts benefit from platinum-based chemotherap.

DRD biomarker-positive mUC patients without cancer progression within 10 weeks of chemotherapy were randomized (1:1) to rucaparib (600 mg twice daily) or placebo and maintained until disease progres.

Of the 248 patients, 74 (28%) were positive for the DRD biomarker, 40 of whom were randomized into two groups (20 in each group.

In the safety population (n=39), treatment-related adverse reactions were more or less low-grad.

In conclusion, maintenance therapy with lucaparib after platinum-based chemotherapy can prolong the progression-free survival of patients with DRD biomarker-positive mUC, and it is well tolerate.

Original source:

Simon .

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