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J Clin Oncol: Ivosidenib is safe for the treatment of gliomas and can slow down the growth rate of tumors

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Diffuse glioma is a malignant brain tumor, including low-grade glioma (LGG) and glioblastoma.

The study included 66 patients with advanced glioma, ivosidenib was administered orally every day for a period of 28 days.

The results showed that ivosidenib was well tolerated and no dose-related toxicity was reported.

Among patients with non-enhanced glioma (n = 35), the objective response rate was 2.

The median progression-free survival in the non-enhanced and enhanced glioma cohorts were 13.

In summary, the results of this study show that in patients with mIDH1 advanced glioma, ivosidenib 500 mg once a day has good safety, prolongs the time of disease control, and reduces the growth rate of non-enhanced tumors.

Original source:

Ingo K Mellinghoff, et al.

ncbi.

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