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J Clin Oncol: Inguinal radiotherapy can replace lymph node dissection for vulvar cancer patients with micrometastasis of sentinel lymph nodes

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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The Groningen International Sentinel Lymph Node Study for Vulvar Cancer (GROINSS-V)-II explored whether inguinal femoral lymph node radiotherapy is a safe alternative to inguinal lymph node resection (IFL) for patients with vulvar cancer with sentinel lymph node (SN) metastasis

GROINSS-V-II is a prospective, multi-center, phase 2 single-arm therapeutic trial that included patients with early-stage vulvar cancer (diameter <4 cm).

Cumulative recurrence rate of ipsilateral groin in patients treated with IFL±RT or RT

From December 2005 to October 2016, a total of 1535 eligible patients were registered, of which 322 (21.

Among the 10 patients with isolated recurrence, 9 had SN metastases> 2 mm and/or extracapsular spread.

The prognosis of the patients in the study cohort: A) disease-specific mortality; (B) overall survival

The researchers modified the treatment plan so that patients with SN large metastases (>2 mm) receive standard care (IFL), while patients with SN micrometastases (≤2 mm) continue to receive inguinal and femoral radiotherapy

Of the 160 patients with SN micrometastases, 126 received inguinal radiotherapy.

Inguinal radiotherapy is a safe alternative therapy for inguinal lymph node dissection in patients with SN micrometastasis, and the treatment-related morbidity is low

Original source:

Maaike HM Oonk, et al.

Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node: Results of GROINSS-V II

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