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J Clin Oncol: Immunogenicity and efficacy of generic cancer vaccines in advanced non-small cell lung cancer

 Last Update: 2022-09-14
 Source: Internet
 Author: User

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Universal Cancer Peptide-Based Vaccine (UCPVax) is a therapeutic cancer vaccine consisting of two highly selective helper peptides that induce CD4+ T helper cell 1 responses

According to the Bayesian-based design of phase IB and IIa phases, patients with refractory NSCLC are assigned to receive three doses of the UCPVax vaccine (0.

A total of 59 patients received UCPVax treatment; 95% of patients have undergone third-line system therapy

Disease control was achieved in 21 (39%) patients (disease stable, n=20; complete remission, n=1

Taken together, the findings suggest that UCPVax is highly immunogenic and safe, and can provide a considerable one-year overall survival rate

Original source:

Olivier Adotévi, et al.

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