J Clin Oncol: Health-related quality of life in Patients with Hodgkin's Lymphoma for 5 Years (HRQoL)

Health-related quality of life (HRQoL) refers to the determination of subjective health status and individual satisfaction associated with individual life events under the influence of disease, accidental injury and medical interventionHealth status and subjective satisfaction constitute the main content, more is the use of self-evaluation, commonly used indicators are subjective indicators, the basis of the establishment is in the individual's certain cultural value system, so it has cultural dependencemany important details of HRQoL after Hodgkin'slymphoma(HL) diagnosis and treatment remain unknown because of the small number of large-scale longitudinal studies of health-related quality of life (HRQoL)As a result, Kreissl et alanalyzed HRQoL and the comprehensive assessment of HL patients at all stages from diagnosis to survival of 5 yearsstudy included HL patients diagnosed between the ages of 18 and 60 in the HD13, HD14 and HD15 trials of the Hodgkin research team in GermanyThe subjects' HRQoL was analyzed through the European Questionnaire on The Study and Treatment of Cancer Quality of Life C30's list of all functions and symptoms (including deviations from the reference values)Multi-regression and repetitive measurements were used to analyze the effects of different diseases, patients and treatment characteristics, and relevance to HRQoL scoresanalyzed 4,215 patients who had an HRQoL assessment within 5 years of treatmentThe high tumor load at the time of diagnosis was associated with the impairment of the base score of multiple HRQoL modulesDuring the survival period, cognitive, emotional, role, and social functions, as well as fatigue, breathing difficulties, sleep and financial problems, were severely affectedStarting from the second year, when the average deviation range of the reference value is between 12-29 points, 10 points is the common threshold for clinical correlationIn three trials, the HRQoL domain after 2 years and 5 years of treatment were significantly affected by baseline scores and age, but not by randomized therapyFatigue is most closely related to other symptoms and levels this study shows that many HL survivors persist with varying degrees of HRQoL defects, which are largely unrelated to the chemotherapy they receive The analysis highlighted the highly unmet medical needs of these young Hodgkin's lymphoma survivors for the psychosocial effects of the cancer experience