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J Clin Oncol: Efficacy and safety of levatinib in the treatment of anaplastic thyroid cancer

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Anaplastic thyroid cancer (ATC), an aggressive malignant tumor, has a poor prognosis.

Lenvatinib (lenvatinib) has been approved by the FDA for the treatment of differentiated thyroid cancer refractory to radioactive iodine, and has also been confirmed to have therapeutic activity in a small-scale ATC patient study (n=17).

FDA

This study aims to further evaluate the efficacy of lenvatinib in patients with ATC .

This study aims to further evaluate the efficacy of lenvatinib in patients with ATC

This is an open-label, international, multi-center phase II study that recruited ATC patients with at least one detectable target lesion and received lenvatinib 24 mg/day

Because the interim analysis did not reach the minimum ORR threshold of 15%, the study was terminated early .

Because the interim analysis did not reach the minimum ORR threshold of 15%, the study was terminated early

Volume change of target lesion

In the overall analysis, one patient achieved a partial response (ORR 2.

Progression-free survival and overall survival

The median progression-free survival was 2.

In summary, the safety of lenvatinib for ATC patients is controllable, but many adverse events have led to the progress of ATC.

Levatinib monotherapy may not be effective in treating ATC Levatinib monotherapy may not be effective in treating ATC

Original source:

Lori J.

org/doi/full/10.
1200/JCO.
20.
03093">Open-Label, Single-Arm, Multicenter, Phase II Trial of Lenvatinib for the Treatment of Patients With Anaplastic Thyroid Cancer in this message

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