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To explore whether preoperative short-course radiotherapy plus chemotherapy is non-inferior to standard long-course concurrent chemoradiotherapy in locally advanced rectal cancer
.
The domestic team carried out a multi-center, randomized controlled clinical study STELLAR, and the relevant research results were published in the Journal of Clinical Oncology
To explore whether preoperative short-course radiotherapy plus chemotherapy is non-inferior to standard long-course concurrent chemoradiotherapy in locally advanced rectal cancer
The study included patients with distal or one-third, stage T3-4 and/or N+ rectal cancer
.
Patients were randomly assigned (1:1) to short-term radiotherapy (25 Gy, divided into 5 sessions over 1 week) followed by 4 cycles of chemotherapy (total neoadjuvant therapy [TNT]) or chemoradiation (50 Gy, divided into 25 sessions over 5 sessions) Weeks, concurrent use of capecitabine [chemochemotherapy; CRT])
The study included patients with distal or one-third, stage T3-4 and/or N+ rectal cancer
Between August 2015 and August 2018, a total of 599 patients were randomly assigned to TNT (n=302) or CRT (n=297)
Of the 465 patients who underwent surgery, 91.
5 % in the TNT group and 87.
8 % in the CRT group underwent R0 resection (p=0.
189)
.
In addition, ypN0 was observed in 71.
Of the 465 patients who underwent surgery, 91.
At a median follow-up of 35.
Subgroup analyses showed that the effects of treatment on OS and PFS were similar regardless of clinicopathological prognostic factors
.
.
Subgroup analyses showed that the effects of treatment on OS and PFS were similar regardless of clinicopathological prognostic factors
During preoperative treatment, the incidence of acute grade III-V toxicity was 26.
5% in the TNT group and 12.
6% in the CRT group (P<0.
001)
.
5% in the TNT group and 12.
6% in the CRT group (P<0.
001)
.
In conclusion, the study shows that for patients with locally advanced rectal cancer, preoperative short-course radiotherapy + chemotherapy (TNT) is a feasible treatment option
.
.
Studies have shown that for patients with locally advanced rectal cancer, preoperative short-course radiotherapy + chemotherapy (TNT) is a feasible treatment option
Original source:
Original source:Jin J, Tang Y, Hu C, et al .
Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR).
J Clin Oncol.
2022 Mar 9:JCO2101667.
doi: 10.
1200/JCO.
21.
01667.
Epub ahead of print.
PMID: 35263150.
Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR).
J Clin Oncol.
2022 Mar 9:JCO2101667.
doi: 10.
1200/JCO.
21.
01667.
Epub ahead of print.
PMID: 35263150.
Jin J, Tang Y, Hu C, et al .
Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR).
J Clin Oncol.
2022 Mar 9:JCO2101667.
doi: 10.
1200/JCO.
21.
01667.
Epub ahead of print.
PMID: 35263150.
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