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J Clin Oncol: busulfan vs systemic radiotherapy plus cyclophosphamide for acute B-lymphoblastic leukemia in adults

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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In patients with acute lymphoblastic leukemia (ALL) who have received allogeneic hematopoietic stem cell transplantation (allo-HSCT), the compatibility of the lebucannum-based protocol with the systemic radiation (TBI)-based protocol remains controversial

This is an open-labeled, randomized Phase 3 clinical trial jointly conducted by 13 hospitals in China, recruiting ALL patients

Between January 2016 and February 2020, 275 patients were assigned to each of the two groups, with 273 in the BuCy group and 272 in the TBI-Cy group included in the assessment

In summary, for adult patients with B-cell ALL who intend to receive HLA-matched allo-HSCT for the standard risk of obtaining the first complete remission, the BuCy protocol has a non-inferior effect and safety profile

Original Source:

Haiyan Zhang, et al.

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