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J Clin Oncol: advanced melanoma with nivolumab combined with ipizumab vs nivolumab therapy

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Both ipilizumab and nalvuzumab have shown therapeutic benefits

In this randomized, double-blind, phase 3 trial, 1833 patients were randomly divided into two groups: 916 in the navulumab plus ipizumab group and 917 in the navulumab monotherapy group; Navulumab (240 mg/2 weeks) plus ipizumab (1 mg/kg·6 weeks) or nalvolumab monotherapy (480 mg/4 weeks) were treated for ≤ 1 year

After a minimum follow-up of approximately 23.

The incidence of grade 3/4 adverse reactions associated with treatment in the combined group and the navulumab monotherapy group was 32.

In summary, navumumab combined with ipizumab therapy did not improve the recurrence rate

Original Source:

Jeffrey S.

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