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J Clin Invest: Fractional laser resurfacing treatment can effectively reduce the risk of non-melanoma skin cancer in aging skin

 Last Update: 2021-12-24
 Source: Internet
 Author: User

Tags

pigmented actinic keratosis

xenograft mouse model

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During human aging, the expression level of insulin-like growth factor 1 (IGF-1) in aging dermal fibroblasts decreases, which is related to the increased risk of non-melanoma skin cancer (NMSC)
.

Recently, researchers from the United States have explored the mechanism by which IGF-1 signaling affects photocarcinogenesis during chronic UVB exposure to determine whether Fractional Laser Resurfacing (FLR) of elderly skin that raises dermal IGF-1 levels can prevent actinization.

The researchers established a human skin/ immune- deficient mouse xenograft model to test the effect of small molecule inhibitors of IGF-1 receptors on chronic UVB radiation
.

Subsequently, the researchers included human subjects 65 years and older to test the durability of FLR treatment

immunity

The results showed that the topical use of IGF-1R inhibitors to treat chronic UVB resulted in carcinogenic reactions
.

A single FLR treatment restores the proper UVB response in elderly skin very long lasting, at least 2 years

In summary, the results of this study show that the elimination of senescent fibroblasts through FLR reduces the carcinogenic response of elderly skin to UVB
.

Therefore, trauma therapy is a potentially effective preventive measure for managing high-risk groups .

Management prevention

Original source:

Dan F Spandau, et al.

, Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia .

Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia in this message

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