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J CEREBR BLOOD FM: Relationship between venous cerebral blood flow quantification and cognition in patients with sickle cell anemia

 Last Update: 2022-01-23
 Source: Internet
 Author: User

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cerebral arteriosclerosis

shelton journal

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Sickle cell anemia (SCA) is the most common monogenic disease worldwide
.

The disease is associated with neurological complications, including stroke, silent cerebral infarction (SCI), and cognitive impairment, all of which can significantly impact social and economic mobility and patient quality of life

Recent evidence suggests that cerebral hemodynamic stress plays an important role in the development of neurological complications in SCA patients, but the mechanism of cerebral hemodynamics is relatively complex and remains unclear

Previous studies have qualitatively characterized high venous signal in SCA patients using arterial spin labeling (ASL), consistent with the signal of arteriovenous shunts
.

Recently, a research article was published in the Journal of Cerebral Blood Flow & Metabolism, an authoritative journal of cerebrovascular and metabolic diseases.

The researchers aimed to quantify the effects and explore cross-sectional associations with arterial oxygen content (CaO2), disease-modifying treatments, silent cerebral infarction (SCI), and cognitive performance

Ninety-four SCA patients and 42 controls underwent cognitive assessment and MRI with single and multiple influx time (TI) ASL sequences
.

Cerebral blood flow (CBF) and bolus arrival time (BAT) were examined in the gray and white matter of the sagittal sinus and in areas of hyperintensity

In the hyperintense sagittal sinus region, CBF also increased with a decrease in CaO2 using both sequences
.

However, in patients in these regions, BAT increased rather than decreased, independent of CaO2

These new findings highlight the utility of multiTI-assessed ASL for elucidating and identifying objective quantitative and functional markers of local hemodynamic stress in SCA patients
.

Original source:

Hanne Stotesbury.

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