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J Autoimmunity: Nuclear translocation of RIG-I promotes apoptosis

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Cell death is important for clearing damaged cells, such as virus-infected cells, and has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE.

In this study, Cao Xuetao's team reported that RIG-I induced nuclear translocation in the late stage of viral infectio.

Taken together, our findings reveal an atypical role for nuclear RIG-I in inducing apoptosis in addition to acting as a cytosolic innate sensor to activate IFN-I expressio.

Source: Wang C, Zhou W, Liu Y, Xu Y, Zhang X, Jiang C, Jiang M, Cao .

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