 Home > Active Ingredient News > Immunology News > J Autoimmunity: Modulation of T cell activation with antisense oligonucleotides targeting lymphocyte cytoplasmic protein 2

J Autoimmunity: Modulation of T cell activation with antisense oligonucleotides targeting lymphocyte cytoplasmic protein 2

 Last Update: 2022-08-19
 Source: Internet
 Author: User

Tags

3 ps

hk 2 cells

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Dysregulated T cell activation is a hallmark of several autoimmune diseases, such as rheumatoid arthritis (RA) and multiple sclerosis (MS.

The researchers identified a set of ASOs targeting the LCP2 3' UTR (designed to be 16 nucleotides long, integrating LNA (locked nucleic acid) nucleotides in a 3-10-3 spacer configuration with fully phosphorothioate (PS) modified backbone), which knocked down LCP2 in the human T cell line Jurkat cells and primary human T cells (monocytes isolated from healthy humans), and found that these inhibited T cell receptor-mediated The induced activation, including the attenuation of NF-κB activation, decreased the mRNA and protein levels of CD69 and CD25 in human T lymphocyte line Jurkat cell.

Taken together, the data from this study provide an example of how to develop immunomodulatory ASOs that interfere with non-druggable targets, and suggest that such drug modalities can be used to treat autoimmune disease.

Credit: Iyer VS, Boddul SV, Johnsson AK, Raposo B, Sharma RK, Shen Y, Kasza Z, Lim KW, Chemin K, Nilsson G, Malmström V, Phan AT, Wermeling .

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

High Purity 99% BPN14770 Zatolmilast 1606974-33-7 In Stock Fast Ship to USA

CAS No.: 1606974-33-7

Pharm Grade

$1-1.1/UNIT FOB

High quality Thymosin α1 Pure CAS 62304-98-7 Thymosin Alpha 1 Thymalfasin

CAS No.: 62304-98-7

Pharmacy Grade

$12-15/UNIT FOB

Top quantity Imiquimod CAS NO 99011-02-6 White crystalline powder 99% API

CAS No.: 99011-02-6

Pharmacy Grade

$1800-1850/KG FOB

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.