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J Autoimmun: Double B-cell targeted therapy improves autoimmune cholangitis

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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Objective: The ability to regulate the development of B cells has long been thought to have therapeutic potential

Methods: ANTI-BAFF and ANTI-CD20 monoclonal antibodies

Results: The data showed that B cell depletion levels with drug combinations increased compared to the use of drugs alone, leading to significantly more effective clinical and serological responses

In summary, the data show that dual B-cell targeted therapy against BAFF and anti-CD20 not only leads to efficient depletion of B cells in peripheral blood and tissues, but also leads to significant clinical improvement

Source: Zhang W, Shao T, Leung PSC, Tsuneyama K, Heuer L, Young HA, Ridgway WM, Gershwin ME.

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