J affect dis: Despite antiretroviral treatment, HIV patients still lose immunity to smallpox

January 23, 2020 / Biovalley BIOON / - -- in a new study, researchers from the University of health and Science in Oregon and the National Primate Research Center in Oregon reported that HIV patients lost immunity to smallpox despite being vaccinated in childhood and having their immune systems restored a lot with antiretroviral therapy (Art) Relevant research results were recently published in the Journal of infectious diseases The title of the paper is "loss of preexisting immunological memory among human immunity virus – infected women aspire immune reconstitution with antivirus therapy" HIV-1 from J Roberto Trujillo / Wikipedia The finding, known as HIV related immune amnesia, may explain why HIV infected people tend to live shorter lives on average than HIV negative people, despite art treatment Before that, scientists have found that the immune system of children infected with measles virus has lost immunity to influenza and other diseases The authors, Dr mark K Slifka, Professor of molecular microbiology and immunology at the University of health and Science in Oregon, and his colleagues compared the T-cell and antibody responses of a total of 100 HIV positive and HIV negative women who had been vaccinated against smallpox in their youth Slifka and his team chose smallpox because its last case in the United States appeared in 1949, which means that the study subjects have not been exposed to smallpox virus recently, otherwise, the virus will trigger new T-cell response and antibody response The Slifka team found that the immune system of HIV positive women on art had a limited response when their blood was exposed to the vaccinia virus used in the smallpox vaccine Under normal circumstances, those vaccinated with smallpox have CD4 T cells that remember the virus and react in large numbers when exposed to it again Previous studies have shown that virus-specific CD4 T cells can last up to 75 years after smallpox vaccination Although art treatment can increase the number of CD4 T cells in HIV positive patients, this finding suggests that although art treatment may increase the total number of T cells, it cannot restore the smallpox specific T cells produced after smallpox vaccination in childhood Slifka and his colleagues plan to assess whether the same has happened in men with HIV, and whether people with HIV also lose immune memory for other diseases (bio Com) reference: 1 Archana Thomas et al Loss of preexisting immunological memory among human immunity virus – infected women aspire immune reconstitution with antivirus therapy Journal of infectious diseases, 2019, doi:10.1093/infdis/jiz678 2.HIV patients lose smallpox immunity despite childhood vaccine, AIDS drugs https://medicalxpress.com/news/2020-01-hiv-patients-smallpox-immunity-childhood.html