I've been through seven drug company safety accidents.

Pharmaceutical enterprises in the industry more than a dozen years, dozens of safety accidents, challenged me a lot of awareness of safety protection and safety protection strategy, this article to the pharmaceutical enterprise first line work as a blueprint, described some of the safety incidents, which also contains some safety protection problems and improvement points, hope to trigger some discussion and thinking.
Event One: You are fumigation in ozone, I am monitoring the environment event description: just work that, I was assigned to the microbiological inspection post, a weekend overtime, press the work plan, I need to measure the cleanness of the preparation area during the day, and then at night the equipment department began ozone fumigation.
weekend company would have worked less, I also feel that a person quite leisurely, in the morning after doing a good job of testing arrangements, the morning began to enter the test ingest of the longest filling test.
after half an hour, I found that the window of someone and I waved, I began to think is to say hello, and then this person evolved into a window, I feel bad, hastened to place good equipment, take off the clean clothes out, after meeting colleagues, he told me that the filling room air conditioning system has begun ozone fumigation, asked me how I still measure the environment inside.
this to me, because I was completely according to the plan, but I have been smoked in it for ten minutes without knowing, completely do not smell ozone ah, is this called warm water boiled frog ... Later, the company leaders know this matter, production manager, equipment manager have come to the company, hush cold askwarm, sent me two boxes of the company's medicine and then took me to the hospital to check the respiratory tract, of course, in the end this thing will not be.
but this thing touched me a lot, if, no one saw me in the clean room, if, I was the first test of the clean room is not the filling room, but there is no window room, I am not yet self-aware, was fumigated. . . This picture is unimaginable.
event analysis: this matter, exposed is the management of the various departments, but at the same time, before fumigation, for the fumigation room personnel clearance confirmation put forward the need for real implementation of the point of view, before hearing that some enterprises, formaldehyde fumigation someone has not come out on faint inside.
therefore, how to correctly implement the environment fumigation, in terms of personnel safety must land, after all, are live life.
event two: filling, need more breathable protective clean clothes event description: for some heat-sensitive products, filling, for the ambient temperature requirements will be lower than the general 18 to 26 degrees C of clean room temperature requirements, if the filling time is long, room ventilation times, air volume, especially for those standing in a large area of rewind air will be particularly cold.
so, I gave us the filling room staff, one person bought a set of warm underwear.
a production of filling, especially not smooth, the size of frequent events, filling team leader a one-meter eight size group busy sweating, sweat wet warm underwear, hoodies, C-grade clean clothes, and even wet the sterile area of B-grade clean clothes.
we all know that if the clean clothes wet, generally re-used clean clothes, in fact, in the clean cloth inside and outside will form a path, so that the protection failure, so, can only out of the filling room, go to the dressing room from inside to outside change, and then back to the filling room to continue to work, in the emergency situation, do not change clothes, change clothes time-consuming, and even lead to the shift in its changing of clothes in the interval of abnormal event handling is not so timely and effective.
event analysis: obviously, this is a consumables configuration problem, because this thing happened, the follow-up I bought them more breathable work underwear, and in the filling room began to use disposable sterile protective clothing, because its material will not be wet, and there is very clear data to prove its high bacterial barrier rate, for sterile products, filling room for personnel is already very human wearing place, that suitable protective clothing is really important, protective clothing, protective production line is also the best protection for employees
event three: spore agent, too stimulating event description: clean room regular large disinfection or encounter pollution events, the first thought is spore ideos, usually the most common formula of spores is hydrogen peroxide and acetic acid mixture, the taste of acetic acid is very stimulating for the respiratory tract.
but most enterprises will only tell employees, you go to use spores disinfectant can be, ask how many leaders, personally experienced the use of spores disinfection is a kind of body sense? Maybe you'll just smell some excess acetic acid in the production corridor and say, Well, it's disinfected again today.
but how many times more stimulus than the concentration you smell? Event analysis: For the operation of the emitted irritating odor solvent employees, the laboratory must operate in the ventilation cabinet, and with a good protective mask, but the clean room disinfection, please give staff can filter the odor of protective masks, to protect the safety of employees.
Event IV: Bottle, I've been bleeding! Description of the incident: a physical and chemical laboratory of an employee operating organic solvent, greedy convenience, bare hands operation, accidentally broke the bottle, in the process of processing, the hand was cut by the bottle glass a big mouth, bleeding more than, because the touch is organic solvent, but also seeped into the wound, the scene pain of wow crying, followed by the hospital washed the wound after stitching two stitches, came back of the leadership education, because he did not operate in accordance with the laboratory regulations.
event analysis: in the operation of organic solvents, first must be armed with gloves, because organic solvents have some damage to the skin, generally will choose purple butyl gloves, butyl this material can be very good to prevent the penetration of organic solvents, but also should be operated in the ventilation cabinet, imagine, if this employee can carry butyl gloves operation, on the one hand to protect the hand skin, even if the bottle is broken, to deal with a solid layer of protection
, therefore, the experimenter can not because the experiment has been very skilled, or simply ignore some of the laboratory's protective measures.
laboratory organic solvents, toxic solvents, these hazardous chemicals, and biosafety protection are very important.
event five: sterilization media, my scalding event description: wet heat sterilization cabinet after reaching a certain temperature, pressure of 0 can open the door to take, microbial medium needs to be removed in time, because long placed in the high temperature environment of the sterilizer, the color of the medium will change color, and will affect the sensitivity of the medium to a certain extent.
to be removed to cool to room temperature, pH needs to be measured to determine that its sterilization value meets the requirements.
an employee of our microbiological laboratory, after the sterilization of the microbial liquid medium removed, did not follow the provisions of SOP, to cool the medium after opening the lid to take sample test pH, but in the medium is very hot when in order to figure time fast, pry open the bottle, the bottle is plug and Aluminum cover packaging, pry open immediately, because of the relationship between the inner pressure of the bottle, hot medium liquid directly splashed into the palm of its hand, resulting in the entire palm of the skin are hot, and even burned to the dermis, turned around a number of hospitals, and finally restored a full 2 months to be good.
event analysis: normal SOP needs to open the bottle cap before confirming the temperature to room temperature, before the hot medium bottle from the sterilization cabinet out, the hand first with a layer of insulated cotton gloves, cotton gloves also need to wear a pair of latex gloves, plus latex gloves are intended to avoid taking liquid flow, will not be caused by direct contact with cotton gloves so that hot liquid seeped into the inside, hot and hot gloves can be isolated.
this event, the person did not follow the established SOP and did not bring the appropriate protective gloves.
the process of handling this matter really let me feel, if the medium splashed on the face, it is really unimaginable.... Event 6: super-clean station on fire! Description of the event: because the use of open flames in the ultra-clean platform, so instead with the air-fire spray gun for some items disinfection, the experimental operator after the experiment, the items will be passed to the transmission window, during which forget to turn off the spray gun, the flame has been on the socket of the ultra-clean platform burning, after looking back, found, The socket has been burned up, in a hurry, the experimenter will sample 1 bottle of injection water at the flame poured up, water extinguished, but the whole line of the ultra-clean station all short circuit, motherboard burned, and finally emergency allocation of an ultra-clean station to THE QC, in order to continue the daily microbiological testing.
event analysis: for the management of the spray gun is not in place, and personnel in the encounter with the situation, the first time should be the super-clean station power cut off, but this kind of event is unpredictable, completely by the first reaction of the parties to do treatment.
the use of super-clean taichung disinfection flame should be put to an end, if you want to use, which is more appropriate? How do I manage it? This is actually a question that I would like to explore.
event 7: hydrochloric acid, you burned my eyes event description: production operation, need to use dilute hydrochloric acid to adjust a solution pH, operator A operation is not appropriate, will be part of the dilute hydrochloric acid liquid thrown out, just splashed into the opposite observation operation of the person B eyes, after the incident, immediately after the incident a large amount of water washed eyes, and then sent to the hospital for a period of time, with a little water, but not serious.
Event Analysis: SOP regulations, when operating hazardous chemicals, should wear protective glasses and masks, operators A and B do not wear protective glasses, may not be a problem with such operations every day, but if there is a problem, that may be a big problem.
in addition, for the workshop on-site management personnel, daily inspection, it is bound to know that we do not wear protective glasses, indicating that their sense of protection is lacking.
the above zero total events, no more than two aspects of the security protection awareness is not in place personnel awareness, the need for clear SOP and repeated training, the combination of the two aspects gradually improve 2, protective measures and protective equipment inadequate In fact, a lot of protective measures must be done in front, the corresponding protective equipment should be in place, after the addition, it must be in the pay some price, some may be saved, but there are some unfortunate, but it is not a real lying.
pharmaceutical companies, this is the production of medicine and rescue drugs, before protecting our drugs, please protect our employees.
just like our new crown outbreak, high-quality protective products make more medical workers protected, so that they can effectively participate in the fight against the epidemic, fulfill their responsibilities, play their advantages.
in pharmaceutical companies, protective supplies can ensure that pharmaceutical company personnel by scientific and effective protection, then our pharmaceutical company personnel, can better for our drug production escort, the output of people at ease, safe and effective drugs.
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