It's really silly to stay up late!

Staying up late is the most common way of life for researchers. Some of them even turn it upside down day and night. Out of the helplessness of experimental study, some are used to it. The later the night, the more energetic they are.but if this goes on like this, you will become stupid slowly! Why do we stay up late and wake up early and feel drowsy? Science, a leading journal, published a study by Professor Laura Lewis of the Department of Biomedical Engineering at Boston University's School of engineering. They found that during sleep, the brain self-cleaning process, and some garbage, including amyloid beta, which causes Alzheimer's disease, is removed.for the first time, they photographed the process of self-cleaning of the brain during sleep: such cleaning can only be done after sleeping, which makes people wake up and have a fresh brain; when they are not asleep, cerebrospinal fluid does not have a full opportunity to enter.so research dogs, sleep more, don't stay up late.if you can't finish brainwashing, you may become stupid.why can you only wash your brain when you are asleep? After you fall asleep, your brain will go through several different stages: through the period of falling asleep, the period of shallow sleep, and then to the period of deep sleep and deep sleep, we will enter the rapid eye movement (REM) sleep period, which is a state of easy dreaming.and scientists call the first four stages "non REM".this new study focuses on the non REM stage, which is very important for the brain's memory retention.in fact, studies in 2013 have proved that toxins such as amyloid beta protein in the brain of mice can be removed during sleep.the detergent used for the brain is called cerebrospinal fluid.the question is, how is it removed? Why can only be cleared when sleeping? The scientists did an experiment in which 13 humans wore EEG caps and slept in an MRI machine.EEG shows which sleep state a person is in, while MRI measures blood oxygen levels and shows how much cerebrospinal fluid is flowing in and out.and then we found a wonderful phenomenon: the blood oxygen concentration in the brain has a significant large cycle change.that is, blood flows out of the brain on a large scale and periodically.at this time, cerebrospinal fluid will rush into the brain and fill the space left for it: green is the signal of blood oxygenation, purple is the signal of cerebrospinal fluid. After waking up, the large cycle is gone, cerebrospinal fluid can not rush into the brain in large quantities and complete the effective cleaning: Laura Lewis, the corresponding author of the paper It is thought that this is because during sleep, neurons in the brain start to synchronize, turn on and off together.the reason for this hypothesis is that the flow of blood and cerebrospinal fluid occurs only after the emergence of nerve rhythm according to EEG data: when a large number of neurons stop stimulating together, so much blood is not needed to deliver oxygen, which gives the opportunity for cerebrospinal fluid to flow in.in this way, we have the picture we saw at the beginning: this discovery is very important, it tells us that sleep is a very special function: when we are awake, neurons do not switch on and off at the same time. therefore, there is no way to reduce brain blood volume to a low enough level when awake. only when there is not so much blood in the brain after sleep can the cerebrospinal fluid circulate freely and remove metabolic by-products such as amyloid beta. previously, the drug development for amyloid beta protein has been in trouble frequently, and the deepening of this research has also opened up new therapeutic ideas for the treatment and prevention of neurological diseases such as Alzheimer's disease and autism: perhaps it is not focused on the specific molecules, but on increasing the total amount of cerebrospinal fluid for "brainwashing", which will become an effective solution 。 OK, after reading this tweet, you can also wash and sleep... From today on, you will no longer stay up late. Source: the Central Committee of the Communist Youth League, qubit, people's daily microblog, etc