It's hammered!

Men are tired, men are tired, the whole world knows that I am tired of making money! Immugent was humming this lyric silently in his heart as he wrote this tweet

Complaining a bit more, let's get down to business

Today, Immugent will talk about the biological mechanism behind the gender differences in different tumor patients through a systematic interpretation of 4 recently published major studies

01

Male receptor models resist targeted therapy

In fact, there has always been research on gender differences in tumors.

Androgen receptor hinders tumor immunotherapy

At first, after reading the previous study, I thought that was the same thing.

induce tumor-infiltrating cells

Tumor-infiltrating immune cells are an important factor affecting the occurrence and development of tumors, but the role of the immune system on tumors is a double-edged sword, which includes not only NK and CD8+ T cells that directly kill tumors, but also promote tumor growth.

04

Androgen receptor may influence antitumor immune response by affecting CD8+ T cell stemness

The last study was done by domestic scholars, which also focused on androgen receptors expressed on CD8+ T cells

05

Outlook

In humans, the presence of the Y chromosome defines sex, because the male-specific Y chromosome carries an SRY gene that expresses the testis determinant

Don't want to miss the hotspots and technologies every day.

Character topic

• A full summary of academician Dong Chen's research results • A full summary of Zhang Zemin's series of research results

Immunization Topics

• The second area immunotherapy pure bio-information mining • 6+ multi-omics immunotherapy

space metabolism

• Single-cell sequencing combined with spatial transcriptome sequencing • Spatial metabolism + drug resistance

Iron Death Topic

• Summary of Iron Death articles • Classic Iron Death, and new ideas

m6A Topic

• Integrative bioinformatics analysis of m6A regulators • The same m6A glioma why the higher

Research acceleration

• How bioinformatics can speed up research projects • Essential skills for clinical research wet experiments

irAEs Topic

• irAEs: overview • irAEs: signatur

For more information on bioinformatics analysis: 18501230653 (same number on WeChat)
[Reference][1] Vellano CP, White MG, Andrews MC, Moran AE, Wang L, Heffernan TP, Marszalek JR, Wargo JA.
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.
Nature.
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Epub 2022 Jun 15.
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[2] Guan X, Polesso F, Wang C, Sehrawat A, Hawkins RM, Murray SE, Thomas GV, Caruso B, Thompson RF, Wood MA, Hipfinger C, Hammond SA, Graff JN, Xia Z, Moran AE.
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Nature.
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[4] Yang C, Jin J, Yang Y, Sun H, Wu L, Shen M, Hong X, Li W, Lu L, Cao D, Wang X, Sun J, Ye Y, Su B, Deng L.
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity.
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e9.
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