It was first confirmed that lncrna can encode polypeptide in cancer cells

Lncrna is a kind of noncoding RNA product whose length of transcripts is more than 200nt Although it does not encode expressed proteins, it can regulate various life activities such as embryonic development, cell proliferation, metastasis and differentiation at multiple levels such as transcription, post transcription and chromosome modification Its abnormal expression is closely related to the occurrence and development of many kinds of tumors Researchers from the Third Affiliated Hospital of Guangzhou Medical University published an article entitled "a peptide encoded by a putative lncrna hoxb-as3 supplies colon cancer growth" For the first time, it was confirmed that an lncrna can encode a polypeptide in a tumor, and it was found that assuming that lncrna hoxb-as3 encodes a 53 amino acid conservative polypeptide This peptide, rather than its lncrna, can inhibit the growth, clonal formation, invasion and metastasis of colon cancer cells This research result was published in molecular cell magazine, and was completed by a team led by Professor Yan Guangrong, the Third Affiliated Hospital of Guangzhou Medical University Professor Yan Guangrong's doctoral student, Jin Zhou, and technician, Chen Min, master, Professor Chen de and Professor Gao Xingcheng are the co authors of this paper, and Professor Yan Guangrong is the corresponding author This work was supported by NSFC, Guangzhou major collaborative innovation project of industry, University and research, Guangzhou "Yangcheng scholars" talent project, Guangzhou education system innovation team and Guangdong science and technology plan In the past few years, there have been some sporadic reports about the research that noncoding RNA is predicted to be able to encode some small peptides In February 2015, Eric n Olson research group of Southwest Medical Center first reported that a specific expression of lncrna in skeletal muscle can encode small peptides After that, relevant research has officially entered the field of vision Recently, some studies have shown that cyclic RNA can also encode some small peptides
However, there is no relevant research report on whether the small peptide encoded by lncrnas plays an important role in the regulation of tumorigenesis and development This study revealed that lncrna coding can encode active anticancer polypeptides, regulate mRNA selective cleavage and switch the glycometabolism pathway of tumor cells, and enrich and broaden the understanding of lncrna action mode and functional mechanism Professor Yan Guangrong has presided over more than 20 high-level scientific research projects such as the National Natural Science Foundation and 973 sub projects The first or corresponding author has published nearly 30 SCI papers in Mol Cell, J Pathol and other journals Cancer is so smart that it's going to do everything possible to survive and use every part of our genome If we only focus on the protein coding genes that make up 2% of the genome, we will have a very limited understanding of the survival mechanism of cancer Without understanding the other 98% of our genome, we can't get individualized cancer treatment Because of their unknown functions outside the protein coding genes, 98% of these regions used to be called "junk DNA", but more and more studies have proved that lncrna is closely related to cancer Recently, a group of researchers also confirmed the role of lncrnas gene in the activation of disease process They examined genetic variations associated with prostate cancer and found that half of the variation was likely to function through non coding genes rather than protein coding genes In other words, the researchers found that noncoding RNA plays an important role in driving prostate cancer formation and disease development.