It is found that the evolution of human immune system has "side effects"

The human immune system has been evolving, which can help us better resist some diseases, but also has some "side effects" Changes in DNA fragments associated with the evolution of the immune system may make people more susceptible to certain autoimmune diseases, a new study suggests Researchers from the University of Nijmegen in the Netherlands published a paper in the new issue of immunology trend, saying that they investigated relevant data in the fields of genetics, immunology, microbiology and virology, and analyzed how the DNA related to infectious pathogens in the genome of some populations in Africa and Eurasia changed in the evolution process Although these changes make people not easy to be infected by some pathogens, they may be related to Crohn's disease, lupus erythematosus and other self inflammatory diseases Autoimmune diseases are recurrent or persistent inflammatory diseases caused by inherent immune system defects or disorders "It seems to be a balance The human immune system has evolved to fight against disease, but it can't stop it On the one hand, we get benefits, on the other hand, we are more sensitive to some new diseases " According to Jorge Dominguez Andres, the first author of the paper and a researcher at the University of nimegan in the Netherlands For example, the researchers say that Africans have been infected with Plasmodium for a long time, so many people's DNA can be evolved to resist Plasmodium by making their bodies inflamed, but this also makes modern Africans more vulnerable to cardiovascular diseases such as atherosclerosis in their later years Another example is that some people in Eurasia carry DNA from Neanderthals They are more resistant to HIV-1 and Staphylococcus, but they are also more prone to allergies, asthma, pollinosis and other problems Researchers say the next generation of gene sequencing technology is booming, which will help scientists understand the relationship between DNA evolution and human diseases at a deeper level.