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The development of the Great Wall Cardiology Conference is a magnificent history of struggle passed down from generation to generation
Hu Dayi
This year is the 32nd Great Wall Cardiology Conference.
On the afternoon of October 28th, Professor Liu Tong from Beijing Anzhen Hospital Affiliated to Capital Medical University brought a topic worthy of attention-"The Cardio and Kidney Protective Effect of Finnelrone "
The cardio-renal protective effect of fennelrone, Professor Liu Tong from Beijing Anzhen Hospital, Capital Medical University
2021 Great Wall Meeting, (right) Professor Liu Tong
2021 Great Wall Meeting, (right) Professor Liu TongProfessor Liu Tong believes that our heart vascular disease burden heavy proteinuria is an independent predictor of cardiovascular (CV) risk, proteinuria increased warning endothelial damage and high risk for cardiovascular disease already exists, the early detection of urinary protein is a blood vessel An important indicator for endothelial injury and CVD risk screening
Heart blood vessels albuminuria is an independent predictor of cardiovascular (CV) risk, proteinuria increased warning endothelial damage and high risk for cardiovascular disease already exists, the early detection of urinary protein vascular endothelial injury and CVD risk screening important indicator of
In cardiovascular patients, the risk of CV in patients with type 2 diabetes increases by 2 to 4 times.
In cardiovascular patients, the risk of CV in patients with type 2 diabetes increases by 2 to 4 times.
So, why is the risk of CV significantly increased in patients with proteinuria?
Professor Liu Tong explained that the production of proteinuria means that the filtration barrier is damaged and the vascular endothelium is damaged
Metabolic syndrome
The excessive activation of mineralocorticoid receptor (MR) is an important mechanism leading to cardiovascular endothelial function damage and cardiovascular events
Cardiovascular events inhibiting the excessive activation of MR are essential for inhibiting vascular endothelial damage, reducing the risk of CV, and delaying CVD
Inflammation and fibrosis extensively affect the kidneys, blood vessels and heart, leading to glomerulus, renal tubular damage, proteinuria, renal blood flow changes and kidney damage, leading to vascular damage such as vascular remodeling, endothelial dysfunction, and hardening of blood vessel walls; At the same time, it can also cause cardiac damage such as myocardial hypertrophy, ventricular remodeling, reduced coronary blood flow, myocardial ischemia/infarction, and myocardial injury
Professor Liu Tong explained a FIGARO study, which is a global, multi-center, large-scale phase III clinical study of Finerenone in type 2 diabetic patients with nephropathy.
In patients with type 2 diabetes and nephropathy, on the basis of giving good blood pressure and blood sugar control, and maximizing RASI treatment, the use of Finerenone significantly reduces cardiovascular composite end points (cardiovascular death, non-fatal myocardial infarction , non -fatal myocardial infarction) .
All in all, the new generation of Fez-based MAR-Finerenone can effectively and accurately inhibit MR, bringing full benefits to the heart and kidneys
The new generation of Fez-based MAR-Finerenone can effectively and accurately inhibit MR, bringing full benefit to the heart and kidneys
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