It has been found that protein may activate cancer cell metastasis

According to a new study by researchers at the Montreal Institute of Neurology and McGill University, a ubiquitous protein in human cells may be an important switch that can activate cancer cell metastasis So far, this important discovery has been largely ignored The discovery of the role of this protein has significantly expanded our understanding of epithelial cancer, such as breast cancer and lung cancer   This study found the function of dennd2b protein During the development of children, dennd2b may play a role in the normal migration of cells In adults, cell migration is greatly reduced, but in the case of cancer, unnecessary cell migration occurs, which can promote tumor cells to move to new sites   Dennd2b activates another protein, rab13, which promotes cell migration So far, we don't know how rab13 can activate cell migration   The researchers found an abnormally high level of rab13 expression in many types of cancer, particularly epithelial cancers that often metastasize to the brain It's important to understand where rab13 is turned on in the cell, and where it's activated, which is important for how it works It was found that dennd2b activated rab13 at the leading edge of cells   Lead researcher Dr McPherson believes rab13 may be the focus of cancer therapy research in the future The researchers injected mice with breast cancer cells that contained high levels of rab13 protein, as well as invasive breast cancer cells that had been artificially removed by rab13   In the case of breast cancer cells with lower rab13 levels, the cancer did not grow or could only form a smaller tumor In addition, the smaller tumors formed did not metastasize to other tissues Prior to this study, no one believed that rab13 played an important role in cancer, Dr McPherson added, adding that the new findings will drive clinical trials   Protein is an important component of all cells and tissues in human body All important parts of the body need to be involved in protein Generally speaking, protein accounts for about 18% of the total mass of human body The most important thing is that it is related to life phenomena   Protein is the material basis of life, is an organic macromolecule, is the basic organic substance of cell, is the main undertaker of life activities There is no life without protein Amino acids are the basic components of proteins It is closely related to life and various forms of life activities Protein is involved in every cell and every important part of the body Protein accounts for 16% ~ 20% of human body weight, that is, a 60kg adult has about 9.6 ~ 12kg protein in its body There are many kinds of proteins in the human body, with different properties and functions, but they are all composed of more than 20 amino acids (amino acid) in different proportions, and they are constantly metabolized and renewed in the body.