Isolation of cancer cell killing virus from mosquitoes in Hainan Province by Sun Yat sen University

After 10 years of intensive research, a natural virus was isolated from the research group of Professor Yan Guangmei, Medical College of Zhongshan University It can selectively infect and kill a variety of cancer cells in vitro, including liver cancer, colorectal cancer, bladder cancer and melanoma, but has no toxic side effects on normal cells The research results were published in the famous international journal Proceedings of the American Academy of Sciences on October 7, 2014 The incidence rate of cancer worldwide is increasing rapidly, and the existing treatment methods are far from meeting clinical needs M1 virus is a natural virus isolated from mosquitoes in Hainan Island, China Professor Yan Guangmei's research team found that this virus can selectively infect and kill a variety of cancer cells in vitro, including liver cancer, colorectal cancer, bladder cancer, melanoma, and has no side effects on normal cells The whole animal experiment showed that the M1 virus injected via tail vein could significantly enrich in tumor tissue and inhibit tumor growth, while the normal organs were not affected The results of this study are of great significance to elucidate the mechanism of selective killing of new natural oncolytic virus M1 on tumor cells and to develop new targeted antitumor drugs, but it is still a long way from clinical application Wang Liping, director of the health management center of Haikou People's Hospital, explained that in theory, there are virus resistant proteins on the surface of human cells, while there are fewer anti-virus proteins on the surface of cancer cells, so the anti-virus ability is relatively poor The specific virus isolated by Sun Yat sen University can consume the nutrients of cancer cells, consume cancer cells, and kill cancer cells "The research of this anti-cancer virus has just made new progress, and it is still a long way from clinical practice." Wang Liping said that if a new anti-cancer drug is to be used in the clinic, it needs strict clinical trials, usually 12-14 years At present, targeted drugs are still the main way to treat cancer They are high-tech drugs with the development of modern molecular biology and cell biology According to Lin Yuan, a doctoral student of Yan Guangmei's research group, M1 virus was isolated from Culex pipiens in 1964 when the Department of Microbiology of Sun Yat sen University studied mosquito borne virus in Hainan Island Around 2004, Yan Guangmei's research team began to study the virus, published the first paper in 2008 and the second paper on October 6, 2014, which took at least three years On October 14, Liu Xinyuan, a researcher at the Institute of Biochemistry and cell biology, Shanghai Institute of life sciences, Chinese Academy of Sciences and academician of the Chinese Academy of Sciences, told the surging news that because oncolytic viruses can proliferate infinitely in cells, burst and dissolve cells, they are called "oncolytic viruses" All viruses can be transformed into oncolytic viruses Lin Yuan said that the experiment found that M1 virus can inhibit up to 90% of human cancer cells cultured in vitro and 50% - 60% of cancer cells in tumor model mice They also cultured the excised tumor tissue in vitro and treated it with M1 virus in clinical cases It was found that the inhibition rate of cancer tissue in sensitive cases was 60% - 70% Lin Yuan said that the research of Yan Guangmei's research team on the virus is only a part of the preclinical work It also needs to carry out research on drug metabolism, pharmacokinetics, pharmaceutics and other aspects before applying for clinical trials Only after passing the strict three-phase clinical trials can it be officially put on the market Therefore, it is difficult to predict the clinical application time "Several years is a must " At present, the tumor still relies on radiotherapy and chemotherapy For this study, the reporter also interviewed a number of tumor experts yesterday According to an expert in radiotherapy and chemotherapy from the Cancer Hospital of CUHK, the research is indeed of breakthrough significance, especially for a variety of cancer cells If it can be used in clinical practice in the future, it is a more ideal treatment method However, the expert also said that at present, the most common cancer treatment is to rely on radiotherapy and chemotherapy to kill cancer cells In recent years, the concept of holistic treatment has been proposed In fact, the above research is also a part of holistic treatment Wu Yilong, a well-known oncology expert in China and vice president of Guangdong People's Hospital, said that at present, cancer treatment has entered the stage of molecular treatment, and gradually entered a more personalized treatment path, aiming at individual differences in drug use, among which the representative is currently more and more targeted treatment methods, "the principle is to find a target for killing, unlike the previous radiotherapy and chemotherapy One large and one large scale of killing, now it is required to kill cells precisely " Wu Yilong also said that although the targeted treatment effect is more significant, the targets that have been found are still limited, and more in-depth molecular cytology research is needed.