ISME Journal Deciphering the ecological responses of the gut microbiome to dietary fiber interventions

On May 21 , the Research Center of Synthetic Microbiology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, and Dai Lei's research group from Shenzhen Institute of Synthetic Biology Innovation published an analysis of intestinal bacteria under the intervention of dietary fiber in the Nature sub-journal ISME J o urna.

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Article link: https://

Dietary fiber has a profound impact on human health, and high dietary fiber intake can reduce the risk of obesity, inflammatory bowel disease, colorectal cancer and other diseas.

Figure 1: Impact of microbial ecology on gut microbiota responses 

The research team analyzed the ecological mechanism of gut microbiota response to dietary fiber intervention through an ecological dynamics mod.

Figure 2: Using an ecodynamic model to analyze the response of mouse gut microbiota to inulin intervention

The research team further applied the ecological model to analyze the time series data of the human gut microbiome under the intervention of dietary fiber, and successfully inferred Bifidobacterium adolescentis with the function of inulin metaboli.

Figure 3: Key bacteria and interaction validation of human gut microbiota under inulin intervention

Aiming at the personalized response phenomenon of gut microbiota under dietary fiber intervention, the study combined time series data and mathematical models to deeply analyze the ecological laws of gut microbio.

This work was supported by the General Program of the National Natural Science Foundation of China ( .

Introduction of PI and research group: 

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The main research direction of Dai Lei's group is the ecology and evolution of the host symbiotic microbiom.

It is planned to recruit 1-2 postdoctoral fellows and 1-2 visiting students with relevant research backgrounds in microbiology, synthetic biology, bioinformatics,e.

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